Iskanje po repozitoriju

A+ | A- | | SLO | ENG

Ključne besede: nanobody rational design, bispecific binders, protein activity inhibition
Objavljeno v RUNG: 03.01.2023; Ogledov: 2592; Prenosov: 7
Celotno besedilo (8,75 MB)
Gradivo ima več datotek! Več...

Opis: Aerosol direct radiative forcing is strongly dependent on aerosol distributions and aerosol types. A detailed understanding of such information is still missing at the Alpine region, which currently undergoes amplified climate warming. Our goal was to study the vertical variability of aerosol types within and above the Vipava valley (45.87◦ N, 13.90◦ E, 125 m a.s.l.) to reveal the vertical impact of each particular aerosol type on this region, a representative complex terrain in the Alpine region which often suffers from air pollution in the wintertime. This investigation was performed using the entire dataset of a dual-wavelength polarization Raman lidar system, which covers 33 nights from September to December 2017. The lidar provides measurements from midnight to early morning (typically from 00:00 to 06:00 CET) to provide aerosol-type dependent properties, which include particle linear depolarization ratio, lidar ratio at 355 nm and the aerosol backscatter Ångström exponent between 355 nm and 1064 nm. These aerosol properties were compared with similar studies, and the aerosol types were identified by the measured aerosol optical properties. Primary anthropogenic aerosols within the valley are mainly emitted from two sources: individual domestic heating systems, which mostly use biomass fuel, and traffic emissions. Natural aerosols, such as mineral dust and sea salt, are mostly transported over large distances. A mixture of two or more aerosol types was generally found. The aerosol characterization and statistical properties of vertical aerosol distributions were performed up to 3 km.
Ključne besede: valley air pollution, aerosol vertical distributions, lidar remote sensing, aerosol identification
Objavljeno v RUNG: 21.07.2022; Ogledov: 2618; Prenosov: 31
Celotno besedilo (5,57 MB)

Opis: This paper complements the existing studies of Bora flow properties in the Vipava valley with the study of Bora turbulence in a lower region of the troposphere. The turbulence characteristics of Bora flow were derived from high resolution Doppler wind lidar measurements during eight Bora wind episodes that occurred in November and December 2019. Based on the vertical profiles of wind velocity, from 80 to 180 m above the valley floor, the turbulence intensity related to all three spatial directions and the along-wind integral length scales related to three velocity components were evaluated and compared to the approximations given in international standards. The resulting turbulence characteristics of Bora flow in a deep mountain valley exhibited interesting behaviour, differing from the one expected and suggested by standards. The intensity of turbulence during Bora episodes was found to be quite strong, especially regarding the expected values for that particular category of terrain. The specific relationship between along-wind, lateral and vertical intensity was evaluated as well. The scales of turbulence in the along-wind direction were found to vary widely between different Bora episodes and were rather different from the approximations given by standards, with the most significant deviations observed for the along-wind length scale of the vertical velocity component. Finally, the periodicity of flow structures above the valley was assessed, yielding a wide range of possible periods between 1 and 10 min, thus confirming some of the previous observations from the studies of Bora in the Vipava valley.
Ključne besede: doppler wind lidar, Bora wind, turbulence intensity, complex terrain, turbulence integral length scale
Objavljeno v RUNG: 05.11.2021; Ogledov: 3320; Prenosov: 45
Povezava na celotno besedilo
Gradivo ima več datotek! Več...

Ključne besede: nanobody framework, modeling, nanobody humanization, CDR grafting
Objavljeno v RUNG: 27.01.2021; Ogledov: 3556; Prenosov: 68
Celotno besedilo (2,00 MB)

Opis: It has been recently proposed that the ejected matter from white dwarf (WD) binary mergers can produce transient, optical and infrared emission similar to the "kilonovae" of neutron star (NS) binary mergers. To confirm this we calculate the electromagnetic emission from WD-WD mergers and compare with kilonova observations. We simulate WD-WD mergers leading to a massive, fast rotating, highly magnetized WD with an adapted version of the smoothed-particle-hydrodynamics (SPH) code Phantom. We thus obtain initial conditions for the ejecta such as escape velocity, mass and initial position and distribution. The subsequent thermal and dynamical evolution of the ejecta is obtained by integrating the energy-conservation equation accounting for expansion cooling and a heating source given by the fallback accretion onto the newly-formed WD and its magneto-dipole radiation. We show that magnetospheric processes in the merger can lead to a prompt, short gamma-ray emission of up to ≈ 1046 erg in a timescale of 0.1-1 s. The bulk of the ejecta initially expands non-relativistically with velocity 0.01 c and then it accelerates to 0.1 c due to the injection of fallback accretion energy. The ejecta become transparent at optical wavelengths around ~ 7 days post-merger with a luminosity 1041-1042 erg s-1. The X-ray emission from the fallback accretion becomes visible around ~ 150-200 day post-merger with a luminosity of 1039 erg s-1. We also predict the post-merger time at which the central WD should appear as a pulsar depending on the value of the magnetic field and rotation period.
Ključne besede: Astrophysics - High Energy Astrophysical Phenomena
Objavljeno v RUNG: 20.07.2020; Ogledov: 4310; Prenosov: 0
Gradivo ima več datotek! Več...