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Outlier based literature exploration for cross-domain linking of Alzheimer's disease and gut microbiota
Donatella Gubiani, Elsa Fabbretti, Bojan Cestnik, Nada Lavrač, Tanja Urbančič, 2017, izvirni znanstveni članek

Opis: In knowledge discovery, experts frequently need to combine knowledge from different domains to get new insights and derive new conclusions. Intelligent systems should support the experts in the search for relationships between concepts from different domains, where huge amounts of possible combinations require the systems to be efficient but also sufficiently general, open and interactive to enable the experts to creatively guide the discovery process. The paper proposes a cross-domain literature mining methodology that achieves this functionality by combining the functionality of two complementary text mining tools: clustering and topic ontology creation tool OntoGen and cross-domain bridging terms exploration tool CrossBee. Focusing on outlier documents identified by OntoGen contributes to the efficiency, while CrossBee allows for flexible and user-friendly bridging concepts exploration and identification. The proposed approach, which is domain independent and can support cross-domain knowledge discovery in any field of science, is illustrated on a biomedical case study dealing with Alzheimer’s dis- ease, one of the most threatening age-related diseases, deteriorating lives of numerous individuals and challenging the ageing society as a whole. By applying the proposed methodology to Alzheimer’s disease and gut microbiota PubMed articles, we have identified Nitric oxide synthase (NOS) as a potentially valuable link between these two domains. The results support the hypothesis of neuroinflammatory nature of Alzheimer’s disease, and is indicative for the quest for identifying strategies to control nitric oxide- associated pathways in the periphery and in the brain. By addressing common mediators of inflammation using literature-based discovery, we have succeeded to uncover previously unidentified molecular links between Alzheimer’s disease and gut microbiota with a multi-target therapeutic potential.
Ključne besede: Literature-based discovery, Outlier detection, Alzheimer's disease, Gut microbiome
Objavljeno v RUNG: 26.05.2017; Ogledov: 5323; Prenosov: 0
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Determination of Trace Cr(VI) with Diphenylcarbazide by μFIA–Thermal Lens Microscopy
Tatyana Gor’kova, Michail Proskurnina, Mingqiang Liu, Mladen Franko, 2016, izvirni znanstveni članek

Opis: The optimum reaction parameters for the interaction of hexavalent chromium [Cr(VI)] with diphenylcarbazide in microfluidic chips (μFIA) with thermal-lens microscopic detection were selected. The characteristic feature of the applied flow scheme is the injection of the reagent into the stream containing the test metal, which enables in-field and real-time monitoring of Cr(VI) simply by flowing the sample continuously through the microchip. The limit of detection of Cr(VI) under the selected conditions (signal generating wavelength, 514.5 nm; excitation power, 100 mW; detection position, 10 cm downstream from the mixing zone of the microchip; flow rate 10 μL min–1; injection volume, 1.4 μL) is 15 ng mL–1 (2.9 × 10–7 mol L–1). The linear range is 40 ng mL–1 – 10 μg mL–1 with a relative standard deviation no higher than 10% in the concentration range 0.1–1 μg mL–1. The online monitoring by this scheme provides the possibility of up to 360 analyses per hour.
Ključne besede: Photothermal lensing, thermal-lens microscopic detection, microfluidic applications, μFIA, hexavalent chromium, diphenylcarbazide
Objavljeno v RUNG: 12.12.2016; Ogledov: 4802; Prenosov: 0
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High Energy Astrophysics
Lili Yang, prispevek na konferenci brez natisa

Opis: I was invited as a lecturer at the Sumer School on Astrophysics and Astroparticles in Petnica Serbia. I gave talks on "High Energy Astrophysics", where I mainly focused on the production, propagation and detection of high energy astroparticles. Especially, I introduced the current experiments and technique and facilities.
Ključne besede: High-energy astroparticles, experiments, detection, production
Objavljeno v RUNG: 06.12.2016; Ogledov: 5810; Prenosov: 0
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