Vaš brskalnik ne omogoča JavaScript!
JavaScript je nujen za pravilno delovanje teh spletnih strani. Omogočite JavaScript ali pa uporabite sodobnejši brskalnik.
Univerza v Novi Gorici
O Univerzi
Študij
Raziskave
Repozitorij Univerze v Novi Gorici
Uvodnik
Iskanje
Brskanje
Statistika
Prijava
Izpis gradiva
A+
|
A-
|
SLO
|
ENG
Naslov:
Molecular dynamics simulations and docking enable to explore the biophysical factors controlling the yields of engineered nanobodies
Avtorji:
Soler, Miguel
(Avtor)
de Marco, Ario
(Avtor)
Fortuna, Sara
(Avtor)
Datoteke:
Soler_et_al-2016-Scientific_Reports.pdf
(1,95 MB)
Jezik:
Angleški jezik
Vrsta gradiva:
Delo ni kategorizirano (r6)
Tipologija:
1.01 - Izvirni znanstveni članek
Organizacija:
UNG - Univerza v Novi Gorici
Opis:
Nanobodies (VHHs) have proved to be valuable substitutes of conventional antibodies for molecular recognition. Their small size represents a precious advantage for rational mutagenesis based on modelling. Here we address the problem of predicting how Camelidae nanobody sequences can tolerate mutations by developing a simulation protocol based on all-atom molecular dynamics and wholemolecule docking. The method was tested on two sets of nanobodies characterized experimentally for their biophysical features. One set contained point mutations introduced to humanize a wild type sequence, in the second the CDRs were swapped between single-domain frameworks with Camelidae and human hallmarks. The method resulted in accurate scoring approaches to predict experimental yields and enabled to identify the structural modifications induced by mutations. This work is a promising tool for the in silico development of single-domain antibodies and opens the opportunity to customize single functional domains of larger macromolecules
Ključne besede:
nanobodies
,
molecular dynamics
,
modeling
,
antibody solubility
Leto izida:
2016
Št. strani:
11
Številčenje:
6:34869 |
COBISS_ID:
4531707
URN:
URN:SI:UNG:REP:LFCPDQKV
DOI:
10.1038/srep34869
Licenca:
To delo je dosegljivo pod licenco
Creative Commons Priznanje avtorstva 4.0 Mednarodna
Število ogledov:
3420
Število prenosov:
212
Metapodatki:
Področja:
Gradivo ni uvrščeno v področja.
Citiraj gradivo
Navadno besedilo
BibTeX
EndNote XML
EndNote/Refer
RIS
ABNT
ACM Ref
AMA
APA
Chicago
Harvard
IEEE
ISO 690
MLA
Vancouver
:
Skupna ocena:
(0 glasov)
Vaša ocena:
Ocenjevanje je dovoljeno samo
prijavljenim
uporabnikom.
Postavite miškin kazalec na naslov za izpis povzetka. Klik na naslov izpiše podrobnosti ali sproži prenos.
Gradivo je del revije
Naslov:
Scientific Reports
Založnik:
Springer Nature Publishing
Leto izida:
2016
Gradivo je financirano iz projekta
Financer:
ARRS - Agencija za raziskovalno dejavnost Republike Slovenije (ARRS)
Program financ.:
Sofinanciranje znanstvenoraziskovalnega sodelovanja med RS in Belgijo
Številka projekta:
N4-0046
Naslov:
Akronim:
ID projekta:
info:eu-repo/grantAgreement/ARRS/Sofinanciranje%20znanstvenoraziskovalnega%20sodelovanja%20med%20RS%20in%20Belgijo/N4-0046
Nazaj