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Title:Cardiac stem cell aging and heart failure
Authors:ID Cesselli, Daniela, Department of Medical and Biological Sciences, University of Udine, Udine, Italy (Author)
ID Aleksova, Aneta, Cardiovascular Department, “Ospedali Riuniti” and University of Trieste, Trieste, Italy (Author)
ID Mazzega, Elisa, Department of Medical and Biological Sciences, University of Udine, Udine, Italy (Author)
ID Caragnano, Angela, Department of Medical and Biological Sciences, University of Udine, Udine, Italy (Author)
ID Beltrami, Antonio Paolo, Department of Medical and Biological Sciences, University of Udine, Udine, Italy (Author)
Files: This document has no files that are freely available to the public. This document may have a physical copy in the library of the organization, check the status via COBISS. Link is opened in a new window
Language:English
Work type:Not categorized
Typology:1.02 - Review Article
Organization:UNG - University of Nova Gorica
Abstract:A side effect of the medical improvements of the last centuries is the progressive aging of the world population, which is estimated to reach the impressive number of 2 billion people with more than 65 years by 2050. As a consequence, age-related diseases, such as heart failure, will affect more and more patients in the next years. To understand the biological bases of these diseases will be a crucial task in order to find better treatments, and possibly slow age-related morbidity and mortality. Cardiac stem cells have been at the center of a heated debate and their potential involvement in cardiac homeostasis has been questioned. In this review, we summarize evidence obtained by independent groups, on different animal models and humans, that strongly support the important role played by immature, cardiac resident cells in the cardioprotection against heart failure.
Keywords:Aging, Heart failure, Cardiomyocyte turnover, Stem cells, Cell senescence, cKit, Sca1, PDGFRα, Cardiospheres
Year of publishing:2017
Number of pages:7
Numbering:XXX
PID:20.500.12556/RUNG-3029-7a927821-2d15-6840-9c70-6d81cbbd28bf New window
COBISS.SI-ID:4759291 New window
DOI:10.1016/j.phrs.2017.01.013 New window
NUK URN:URN:SI:UNG:REP:P7XRQDSR
Publication date in RUNG:28.03.2017
Views:4428
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Record is a part of a journal

Title:Pharmacological Research
Publisher:Elsevier
Year of publishing:2017
ISSN:1043-6618

Licences

License:CC BY-NC-ND 4.0, Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International
Link:http://creativecommons.org/licenses/by-nc-nd/4.0/
Description:The most restrictive Creative Commons license. This only allows people to download and share the work for no commercial gain and for no other purposes.
Licensing start date:20.03.2017

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