Repozitorij Univerze v Novi Gorici

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Naslov:SIGNALING STUDIES IN THE EMERGING KIWIFRUIT PATHOGEN Pseudomonas syringae pv. actinidiae
Avtorji:ID Venturi, Vittorio (Mentor) Več o mentorju... Novo okno
ID Javvadi, Sree Gowrinadh (Avtor)
Datoteke:.pdf Sree_Gowrinadh_Javvadi.pdf (4,41 MB)
MD5: E37B4749BC8C6EB0F05B489BFBD025BB
 
Jezik:Angleški jezik
Vrsta gradiva:Doktorsko delo/naloga
Tipologija:2.08 - Doktorska disertacija
Organizacija:FPŠ - Fakulteta za podiplomski študij
Opis:In the past two decades emerging and re-emerging plant pathogens have caused new threats to the production of several economically important crops, one among them is P. syringae pv. actinidiae (PSA) which causes canker or leaf spot on kiwifruit plants. PSA enters plant through wounds and remains dormant in cortex tissue of the branches, and spreads in the tissue to cause severe symptoms from winter to early spring. The disease can be visualized by brown discoloration of buds, dark brown angular spots surrounded by yellow haloes on leaves, cankers with white to reddish (oxydation) exudate on twigs and trunks, fruit collapse, wilting and eventually plant mortality. Current control methods have their own significance in disease control, however there is considerable lack of clear understanding of PSA pathogenicity. Virulence of plant pathogens often relies on the synchronized/coordinated expression of pathogenicity factors via quorum sensing (QS). Therefore, investigations on QS in PSA may lead to develop novel disease control strategies and reliable methods to curb the disease. It is currently unknown whether PSA produces a QS signal molecule thus the aim of this thesis is to investigate whether PSA possesses a QS system. As genome mining did not reveal the presence of any currently known QS system, this study initially by metabolomics was aimed at identifying potentially low molecular weight secondary metabolite QS molecules produced by PSA. Azelaic acid was discovered to be produced by PSA, this is the first report of azelaic acid production by bacteria. The characterization and possible role of azelaic acid in QS is presented. Since azelaic acid is ubiquitous in nature, in addition to determining its biological role, the catabolism of azelaic acid in bacteria using the efficient degrader Pseudomonas nitroreducens DSM 9128 was also studied.
Ključne besede:Quorum sensing, Azelaic acid, Metabolomics, Catabolism
Kraj izida:Nova Gorica
Leto izida:2017
PID:20.500.12556/RUNG-3486 Novo okno
COBISS.SI-ID:4974587 Novo okno
NUK URN:URN:SI:UNG:REP:ZKM02EHD
Datum objave v RUNG:19.12.2017
Število ogledov:5412
Število prenosov:216
Metapodatki:XML DC-XML DC-RDF
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