Repozitorij Univerze v Novi Gorici

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Naslov:A long-term study on female mice fed on a genetically modified soybean: effects on liver ageing.
Avtorji:ID Malatesta, Manuela, Università di Verona (Avtor)
ID Boraldi, Federica, Università di Modena e Reggio Emilia (Avtor)
ID Annovi, Giulia, Università di Modena e Reggio Emilia (Avtor)
ID Baldelli, Beatrice, Università di Urbino (Avtor)
ID Battistelli, Serafina, Università di Urbino (Avtor)
ID Baggiogera, Marco, Università di Pavia (Avtor)
ID Quaglino, Daniela, Università di Modena e Reggio Emilia (Avtor)
Datoteke: Gradivo nima datotek, ki so prostodostopne za javnost. Gradivo je morda fizično dosegljivo v knjižnici fakultete, zalogo lahko preverite v COBISS-u. Povezava se odpre v novem oknu
Jezik:Angleški jezik
Vrsta gradiva:Delo ni kategorizirano
Tipologija:1.01 - Izvirni znanstveni članek
Organizacija:UNG - Univerza v Novi Gorici
Opis:Liver represents a suitable model for monitoring the effects of a diet, due to its key role in controlling the whole metabolism. Although no direct evidence has been reported so far that genetically modified (GM) food may affect health, previous studies on hepatocytes from young female mice fed on GM soybean demonstrated nuclear modifications involving transcription and splicing pathways. In this study, the effects of this diet were studied on liver of old female mice in order to elucidate possible interference with ageing. The morpho-functional characteristics of the liver of 24-month-old mice, fed from weaning on control or GM soybean, were investigated by combining a proteomic approach with ultrastructural, morphometrical and immunoelectron microscopical analyses. Several proteins belonging to hepatocyte metabolism, stress response, calcium signalling and mitochondria were differentially expressed in GM-fed mice, indicating a more marked expression of senescence markers in comparison to controls. Moreover, hepatocytes of GM-fed mice showed mitochondrial and nuclear modifications indicative of reduced metabolic rate. This study demonstrates that GM soybean intake can influence some liver features during ageing and, although the mechanisms remain unknown, underlines the importance to investigate the long-term consequences of GM-diets and the potential synergistic effects with ageing, xenobiotics and/or stress conditions.
Ključne besede:Genetically modified soybean, liver, mitochondria
Leto izida:2008
Št. strani:967-977
Številčenje:130
PID:20.500.12556/RUNG-4691-b65690e8-864f-ca8e-ecd4-60d24eb15f64 Novo okno
COBISS.SI-ID:5438971 Novo okno
DOI:10.1007/s00418-008-0476-x Novo okno
NUK URN:URN:SI:UNG:REP:CGFYYCW4
Datum objave v RUNG:23.08.2019
Število ogledov:3581
Število prenosov:0
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Gradivo je del revije

Naslov:Histochemical cellular biology
Skrajšan naslov:Histochem Cell Biol
Leto izida:2008

Licence

Licenca:CC BY-NC-ND 4.0, Creative Commons Priznanje avtorstva-Nekomercialno-Brez predelav 4.0 Mednarodna
Povezava:http://creativecommons.org/licenses/by-nc-nd/4.0/deed.sl
Opis:Najbolj omejujoča licenca Creative Commons. Uporabniki lahko prenesejo in delijo delo v nekomercialne namene in ga ne smejo uporabiti za nobene druge namene.
Začetek licenciranja:22.08.2019

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