Repozitorij Univerze v Novi Gorici

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Naslov:Antibiotics and their different application strategies in controlling the biofilm forming pathogenic bacteria
Avtorji:ID Khan, Fazlurrahman, Marine-Integrated Bionics Research Center, Pukyong National University, Busan 48513, Korea (Avtor)
ID T N Pham, Dung, Department of Food Science and Technology, Pukyong National University, Busan 48513, Korea (Avtor)
ID Oloketuyi, Sandra, Laboratory for Environmental and Life Sciences, University of Nova Gorica 5000, Nova Gorica, Slovenia (Avtor)
ID Kim, Young-Mog, Marine-Integrated Bionics Research Center, Pukyong National University, Busan 48513, Korea (Avtor)
Datoteke: Gradivo nima datotek, ki so prostodostopne za javnost. Gradivo je morda fizično dosegljivo v knjižnici fakultete, zalogo lahko preverite v COBISS-u. Povezava se odpre v novem oknu
Jezik:Angleški jezik
Vrsta gradiva:Delo ni kategorizirano
Tipologija:1.02 - Pregledni znanstveni članek
Organizacija:UNG - Univerza v Novi Gorici
Opis:Background: The establishment of a biofilm by most pathogenic bacteria has been known as one of the resistance mechanisms against antibiotics. A biofilm is a structural component where the bacterial community adheres to the biotic or abiotic surfaces by the help of Extracellular Polymeric Substances (EPS) produced by bacterial cells. The biofilm matrix possesses the ability to resist several adverse environmental factors, including the effect of antibiotics. Therefore, the resistance of bacterial biofilm-forming cells could be increased up to 1000 times than the planktonic cells, hence requiring a significantly high concentration of antibiotics for treatment. Methods: Up to the present, several methodologies employing antibiotics as an anti-biofilm, antivirulence or quorum quenching agent have been developed for biofilm inhibition and eradication of a pre-formed mature biofilm. Results: Among the anti-biofilm strategies being tested, the sub-minimal inhibitory concentration of several antibiotics either alone or in combination has been shown to inhibit biofilm formation and down-regulate the production of virulence factors. The combinatorial strategies include (1) combination of multiple antibiotics, (2) combination of antibiotics with non-antibiotic agents and (3) loading of antibiotics onto a carrier. Conclusion: The present review paper describes the role of several antibiotics as biofilm inhibitors and also the alternative strategies adopted for applications in eradicating and inhibiting the formation of biofilm by pathogenic bacteria.
Ključne besede:Antibiotics, biofilm inhibition, multiple antibiotics, pathogenic bacteria, resistance mechanism, virulence factors
Leto izida:2020
Št. strani:17
Številčenje:4, 21
PID:20.500.12556/RUNG-6193 Novo okno
COBISS.SI-ID:47100163 Novo okno
DOI:10.2174/1389201020666191112155905 Novo okno
NUK URN:URN:SI:UNG:REP:A8REEER3
Datum objave v RUNG:14.01.2021
Število ogledov:2432
Število prenosov:0
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Gradivo je del revije

Naslov:Current Pharmaceutical Biotechnology
Skrajšan naslov:Curr Pharm Biotechnol
Leto izida:2020

Licence

Licenca:CC BY-ND 4.0, Creative Commons Priznanje avtorstva-Brez predelav 4.0 Mednarodna
Povezava:http://creativecommons.org/licenses/by-nd/4.0/deed.sl
Opis:Licenca Creative Commons Brez predelav dovoljuje uporabnikom ponovno distribucijo dela, vendar ne v spremenjeni obliki. Zahtevana je navedba avtorstva.
Začetek licenciranja:14.01.2021

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