Repozitorij Univerze v Novi Gorici

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Naslov:Diversity of bacteria and bacterial products as antibiofilm and antiquorum sensing drugs against pathogenic bacteria
Avtorji:ID Khan, Fazlurrahman, Marine-Integrated Bionics Research Center, Pukyong National University, Busan 48513, South Korea (Avtor)
ID Oloketuyi, Sandra, Laboratory for Environmental and Life Sciences, University of Nova Gorica, 5000, Slovenia (Avtor)
ID Kim, Young-Mog, Marine-Integrated Bionics Research Center, Pukyong National University, Busan 48513, South Korea (Avtor)
Datoteke: Gradivo nima datotek, ki so prostodostopne za javnost. Gradivo je morda fizično dosegljivo v knjižnici fakultete, zalogo lahko preverite v COBISS-u. Povezava se odpre v novem oknu
Jezik:Angleški jezik
Vrsta gradiva:Delo ni kategorizirano
Tipologija:1.02 - Pregledni znanstveni članek
Organizacija:UNG - Univerza v Novi Gorici
Opis:The increase in antibiotic resistance of pathogenic bacteria has led to the development of new therapeutic approaches to inhibit biofilm formation as well as interfere quorum sensing (QS) signaling systems. The QS system is a phenomenon in which pathogenic bacteria produce signaling molecules that are involved in cell to cell communication, production of virulence factors, biofilm maturation, and several other functions. In the natural environment, several non-pathogenic bacteria are present as mixed population along with pathogenic bacteria and they control the behavior of microbial community by producing secondary metabolites. Similarly, non-pathogenic bacteria also take advantages of the QS signaling molecule as a sole carbon source for their growth through catabolism with enzymes. Several enzymes are produced by bacteria which disrupt the biofilm architecture by degrading the composition of extracellular polymeric substances (EPS) such as exopolysaccharide, extracellular- DNA and protein. Thus, the interference of QS system by bacterial metabolic products and enzymatic catalysis, modification of the QS signaling molecules as well as enzymatic disruption of biofilm architecture have been considered as the alternative therapeutic approaches. This review article elaborates on the diversity of different bacterial species with respect to their metabolic products as well as enzymes and their molecular modes of action. The bacterial enzymes and metabolic products will open new and promising perspectives for the development of strategies against the pathogenic bacterial infections.
Ključne besede:Bacteria, biofilm, quorum sensing, inhibition, metabolites, pathogen, virulence.
Leto izida:2019
Št. strani:1156-1179
Številčenje:11, 20
PID:20.500.12556/RUNG-6194 Novo okno
COBISS.SI-ID:47521283 Novo okno
DOI:10.2174/1389450120666190423161249 Novo okno
NUK URN:URN:SI:UNG:REP:TYJAD5KU
Datum objave v RUNG:18.01.2021
Število ogledov:2631
Število prenosov:0
Metapodatki:XML RDF-CHPDL DC-XML DC-RDF
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Vaša ocena:Ocenjevanje je dovoljeno samo prijavljenim uporabnikom.
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Gradivo je del revije

Naslov:Current Drug Targets
Skrajšan naslov:Curr. Drug Targets
Leto izida:2019

Licence

Licenca:CC BY-ND 4.0, Creative Commons Priznanje avtorstva-Brez predelav 4.0 Mednarodna
Povezava:http://creativecommons.org/licenses/by-nd/4.0/deed.sl
Opis:Licenca Creative Commons Brez predelav dovoljuje uporabnikom ponovno distribucijo dela, vendar ne v spremenjeni obliki. Zahtevana je navedba avtorstva.
Začetek licenciranja:14.01.2021

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