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Naslov:Breath and plasma metabolomics to assess inflammation in acute stroke
Avtorji:ID Ahmed, Waqar (Avtor)
ID White, Iain R. (Avtor)
ID Wilkinson, Maxim (Avtor)
ID Johnson, Craig (Avtor)
ID Rattray, Nicholas J. W. (Avtor)
ID Kishore, Amit K. (Avtor)
ID Goodacre, Royston (Avtor)
ID Smith, Craig J. (Avtor)
ID Fowler, Stephen J. (Avtor)
Datoteke:URL https://doi.org/10.1038/s41598-021-01268-5
 
Jezik:Angleški jezik
Vrsta gradiva:Neznano
Tipologija:1.01 - Izvirni znanstveni članek
Organizacija:UNG - Univerza v Novi Gorici
Opis:Inflammation is strongly implicated in both injury and repair processes occurring after stroke. In this exploratory study we assessed the feasibility of repeated sampling of exhaled volatile organic compounds and performed an untargeted metabolomic analysis of plasma collected at multiple time periods after stroke. Metabolic profiles were compared with the time course of the inflammatory markers C-reactive protein (CRP) and interleukin-6 (IL-6). Serial breath sampling was well-tolerated by all patients and the measurement appears feasible in this group. We found that exhaled decanal tracks CRP and IL-6 levels post-stroke and correlates with several metabolic pathways associated with a post-stroke inflammatory response. This suggests that measurement of breath and blood metabolites could facilitate development of novel therapeutic and diagnostic strategies. Results are discussed in relation to the utility of breath analysis in stroke care, such as in monitoring recovery and complications including stroke associated infection.
Ključne besede:stroke, metabolomics, breath, VOCs, inflammation
Leto izida:2021
Št. strani:str. 1-14
Številčenje:Vol. 11, 11
PID:20.500.12556/RUNG-6989 Novo okno
COBISS.SI-ID:85403907 Novo okno
UDK:53
ISSN pri članku:2045-2322
DOI:10.1038/s41598-021-01268-5 Novo okno
NUK URN:URN:SI:UNG:REP:9FN36FCD
Datum objave v RUNG:18.11.2021
Število ogledov:1799
Število prenosov:62
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Gradivo je del revije

Naslov:Scientific reports
Skrajšan naslov:Sci. rep.
Založnik:Nature Publishing Group
ISSN:2045-2322
COBISS.SI-ID:18727432 Novo okno

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