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Naslov:Analysis of exhaled breath to identify critically ill patients with ventilator-associated pneumonia
Avtorji:ID Felton, T. W. (Avtor)
ID Ahmed, Waqar (Avtor)
ID White, Iain R. (Avtor)
ID Oort, Pouline M. van (Avtor)
ID Rattray, Nicholas J. W. (Avtor)
ID Docherty, C. (Avtor)
ID Bannard-Smith, Jonathan (Avtor)
ID Morton, J.B. (Avtor)
ID Welters, Ingeborg (Avtor)
ID McMullan, R. (Avtor), et al.
Datoteke:.pdf Anaesthesia_-_2023_-_Felton_-_Analysis_of_exhaled_breath_to_identify_critically_ill_patients_with_ventilator‐associated.pdf (237,72 KB)
MD5: 48926E00BE73AD78CFD386E333F191A2
 
URL https://associationofanaesthetists-publications.onlinelibrary.wiley.com/doi/10.1111/anae.15999
 
Jezik:Angleški jezik
Vrsta gradiva:Neznano
Tipologija:1.01 - Izvirni znanstveni članek
Organizacija:UNG - Univerza v Novi Gorici
Opis:Ventilator-associated pneumonia commonly occurs in critically ill patients. Clinical suspicion results in overuse of antibiotics, which in turn promotes antimicrobial resistance. Detection of volatile organic compounds in the exhaled breath of critically ill patients might allow earlier detection of pneumonia and avoid unnecessary antibiotic prescription. We report a proof of concept study for non-invasive diagnosis of ventilator-associated pneumonia in intensive care (the BRAVo study). Mechanically ventilated critically ill patients commenced on antibiotics for clinical suspicion of ventilator-associated pneumonia were recruited within the first 24 h of treatment. Paired exhaled breath and respiratory tract samples were collected. Exhaled breath was captured on sorbent tubes and then analysed using thermal desorption gas chromatography–mass spectrometry to detect volatile organic compounds. Microbiological culture of a pathogenic bacteria in respiratory tract samples provided confirmation of ventilator-associated pneumonia. Univariable and multivariable analyses of volatile organic compounds were performed to identify potential biomarkers for a ‘rule-out’ test. Ninety-six participants were enrolled in the trial, with exhaled breath available from 92. Of all compounds tested, the four highest performing candidate biomarkers were benzene, cyclohexanone, pentanol and undecanal with area under the receiver operating characteristic curve ranging from 0.67 to 0.77 and negative predictive values from 85% to 88%. Identified volatile organic compounds in the exhaled breath of mechanically ventilated critically ill patients show promise as a useful non-invasive ‘rule-out’ test for ventilator-associated pneumonia.
Ključne besede:breath, diagnosis, ventilator-associated pneumonia
Datum objave:01.01.2023
Leto izida:2023
Št. strani:Str. 712-721
Številčenje:Vol. 78, iss. 6
PID:20.500.12556/RUNG-8103-62c8f7d0-8015-1827-f8c3-8dfaf5f3ef2f Novo okno
COBISS.SI-ID:147847939 Novo okno
UDK:616.2
ISSN pri članku:1365-2044
DOI:10.1111/anae.15999 Novo okno
NUK URN:URN:SI:UNG:REP:FK4U5PBJ
Datum objave v RUNG:05.04.2023
Število ogledov:2478
Število prenosov:20
Metapodatki:XML DC-XML DC-RDF
:
FELTON, T. W., AHMED, Waqar, WHITE, Iain R., OORT, Pouline M. van, RATTRAY, Nicholas J. W., DOCHERTY, C., BANNARD-SMITH, Jonathan, MORTON, J.B., WELTERS, Ingeborg in MCMULLAN, R., 2023, Analysis of exhaled breath to identify critically ill patients with ventilator-associated pneumonia. Anaesthesia [na spletu]. 2023. Vol. 78, no. 6, p. 712–721. [Dostopano 31 marec 2025]. DOI 10.1111/anae.15999. Pridobljeno s: https://repozitorij.ung.si/IzpisGradiva.php?lang=slv&id=8103
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Gradivo je del revije

Naslov:Anaesthesia
Založnik:Blackwell Science
ISSN:1365-2044
COBISS.SI-ID:515009817 Novo okno

Licence

Licenca:CC BY 4.0, Creative Commons Priznanje avtorstva 4.0 Mednarodna
Povezava:http://creativecommons.org/licenses/by/4.0/deed.sl
Opis:To je standardna licenca Creative Commons, ki daje uporabnikom največ možnosti za nadaljnjo uporabo dela, pri čemer morajo navesti avtorja.
Začetek licenciranja:04.04.2023

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