Repozitorij Univerze v Novi Gorici

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Naslov:Engineering of functional nanosnowflakes from gold nanocarriers capped with amino-modified DNA oligonucleotides
Avtorji:ID Loukanov, Alexandre (Avtor)
ID Arahangelova, Velichka (Avtor)
ID Emin, Saim (Avtor)
ID Filipov, Chavdar (Avtor)
Datoteke: Gradivo nima datotek, ki so prostodostopne za javnost. Gradivo je morda fizično dosegljivo v knjižnici fakultete, zalogo lahko preverite v COBISS-u. Povezava se odpre v novem oknu
Jezik:Angleški jezik
Vrsta gradiva:Neznano
Tipologija:1.01 - Izvirni znanstveni članek
Organizacija:UNG - Univerza v Novi Gorici
Opis:Abstract The design, engineering and electron microscopic characterization of anisotropic nanosized snowflake‐like structural assemblies (nanosnowflakes) is reported. They were fabricated through immobilization of double stranded amine‐modified and thiol‐terminated DNA oligonucleotides on the surface of ultra‐small isotropic gold nanoparticles used as nanocarriers. The transmission electron microscopy images combined with spectrophotometric data revealed the formation of self‐assembled structural aggregation between individual ligands‐coated nanoparticles. They act as seeds for the further spontaneous dendritic growth in different directions. Their anisotropic morphology is formed due to the occurrence of facilitated electrostatic interactions between positive charged amino‐groups and the negative sugar‐phosphate backbone of oligonucleotides. Thus, nanosnowflakes with size distribution between 40 and 80 nm were obtained. The microscopic analysis demonstrated also that the stable nanosnowflakes structure was highly dependent on the solution ionic strength, which effect the charge fluctuation within the assembly. The reported DNA functionalized nanostructures have potential to be applied as a platform for development of therapeutic materials, as well as drug delivery nanosystems. Research Highlights The engineering, fabrication, and microscopic characterization of DNA nanosnowflakes is reported. The electron microscopy analysis revealed formation of self‐assemblies with anisotropic morphology. The nanosnowflakes size distribution was between 40 and 80 nm.
Ključne besede:DNA, nanocarrier, functionalization, drug delivery
Status publikacije:Objavljeno
Verzija publikacije:Objavljena publikacija
Datum objave:01.01.2023
Leto izida:2023
Št. strani:str. 1169-1176
Številčenje:Vol. 86, issue 9
PID:20.500.12556/RUNG-8944 Novo okno
ISSN:1059-910X
COBISS.SI-ID:189340419 Novo okno
UDK:54
ISSN pri članku:1059-910X
eISSN:1097-0029
DOI:10.1002/jemt.24390 Novo okno
NUK URN:URN:SI:UNG:REP:XBDFAGUO
Datum objave v RUNG:18.03.2024
Število ogledov:424
Število prenosov:0
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Gradivo je del revije

Naslov:Microscopy research and technique
Skrajšan naslov:Microsc. res. tech.
Založnik:Wiley-Liss
ISSN:1059-910X
COBISS.SI-ID:1730383 Novo okno

Licence

Licenca:Drugo
Opis:http://onlinelibrary.wiley.com/termsAndConditions#vor
Začetek licenciranja:21.07.2023

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