Repozitorij Univerze v Novi Gorici

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Naslov:A porous organic polymer for synergistic light-triggered NO release and anticancer drug delivery : lecture at the iCeMS Retreat 2024, Kobe, Japan, 4. 7. 2024
Avtorji:ID Škorjanc, Tina (Avtor)
Datoteke:URL https://icemscd.notion.site/iCeMS-Retreat-2024-42ee04e745fb44b99c40c08cf15d4409
 
Jezik:Angleški jezik
Vrsta gradiva:Neznano
Tipologija:3.15 - Prispevek na konferenci brez natisa
Organizacija:UNG - Univerza v Novi Gorici
Opis:Treatment of biologically complex diseases, such as cancer, can significantly benefit from combination therapies. These powerful therapies are able to simultaneously target different biological targets, thereby overcoming or reducing drug resistance, decreasing dose-related toxicity, and potentially exhibiting synergistic effects. Herein, we combine the effects of nitric oxide (NO) gas therapy and an anticancer drug Doxorubicin (Dox) using a porous organic polymer (POP) as a delivery vehicle for both. SH-POP, synthesized by a facile, room-temperature method, is rich in both thiol (-SH) and secondary amine (R-NH-R’) functional groups, which can be post-synthetically nitrosylated in a room-temperature reaction that uses water as a solvent, yielding SNO-POP. Fourier-transform infrared (FT-IR) and Raman spectroscopy confirm that both types of functional groups are nitrosylated. Upon white light irradiation, SNO-POP releases up to ~60 µmol of NO per g, and exhibits reversible switch on – switch off NO release behavior triggered by simple light irradiation for at least 20 cycles. Unlike many conventional systems, where a known small-molecule NO donor is incorporated into the pores, here, the porous polymer itself serves as a NO donor, so the pores remain available for the encapsulation of another therapeutic, i.e. Dox. The release of Dox from the Dox@SNO-POP system is pH-sensitive and occurs preferentially in a slightly acidic environment (pH = 5.4). HeLa cancer cell viability studies confirm an enhancement in toxicity that can be ascribed to the synergistic effects of light-triggered NO release and pH-triggered Dox release. Confocal microscopy imaging reveals the presence of both species inside cells. This study is expected to stimulate the development of porous polymers as potent vehicles for combination therapies in cancer treatment and beyond.
Ključne besede:porous organic polymer, nitric oxide, combination therapy, synergistic therapy, chemotherapy
Leto izida:2024
PID:20.500.12556/RUNG-9179 Novo okno
COBISS.SI-ID:200850947 Novo okno
UDK:54
NUK URN:URN:SI:UNG:REP:31JHIDGK
Datum objave v RUNG:05.07.2024
Število ogledov:200
Število prenosov:1
Metapodatki:XML RDF-CHPDL DC-XML DC-RDF
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Gradivo je del monografije

Naslov:Institute for Integrated Cell-Material Sciences (iCeMS) Annual Retreat
Kraj izida:Kobe, Japan
Leto izida:2024

Gradivo je financirano iz projekta

Financer:Drugi - Drug financer ali več financerjev
Program financ.:Japanese Society for Promotion of Science
Številka projekta:P23743

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