Repozitorij Univerze v Novi Gorici

Izpis gradiva
A+ | A- | Pomoč | SLO | ENG

Naslov:Functional characterisation of surfactant protein A as a novel prophylactic means against oncogenic HPV infections
Avtorji:ID Carse, Sinead (Avtor)
ID Reid, Tim (Avtor)
ID Madsen, Jens (Avtor)
ID Clark, Howard (Avtor)
ID Kirjakulov, Artur (Avtor)
ID Bergant Marušič, Martina (Avtor)
ID Schäfer, Georgia (Avtor)
Datoteke:URL https://www.mdpi.com/1422-0067/25/14/7712
 
.pdf ijms-25-07712-published2024Sinead.pdf (6,10 MB)
MD5: 8A0D589A3E3A66D6742CA96470700FF1
 
URL https://www.mdpi.com/1422-0067/25/14/7712/pdf
 
Jezik:Angleški jezik
Vrsta gradiva:Neznano
Tipologija:1.01 - Izvirni znanstveni članek
Organizacija:UNG - Univerza v Novi Gorici
Opis:Human papillomavirus (HPV) infection poses a significant health challenge, particularly in low- and middle-income countries (LMIC), where limited healthcare access and awareness hinder vaccine accessibility. To identify alternative HPV targeting interventions, we previously reported on surfactant protein A (SP-A) as a novel molecule capable of recognising HPV16 pseudovirions (HPV16-PsVs) and reducing infection in a murine cervicovaginal HPV challenge model. Building on these findings, our current study aimed to assess SP-A’s suitability as a broad-spectrum HPV-targeting molecule and its impact on innate immune responses. We demonstrate SP-A’s ability to agglutinate and opsonise multiple oncogenic HPV-PsVs types, enhancing their uptake and clearance by RAW264.7 murine macrophages and THP-1 human-derived immune cells. The SP-A opsonisation of HPV not only led to increased lysosomal accumulation in macrophages and HaCaT keratinocytes but also resulted in a decreased infection of HaCaT cells, which was further decreased when co-cultured with innate immune cells. An analysis of human innate immune cell cytokine profiles revealed a significant inflammatory response upon SP-A exposure, potentially contributing to the overall inhibition of HPV infection. These results highlight the multi-layered impact of SP-A on HPV, innate immune cells and keratinocytes and lay the basis for the development of alternative prophylactic interventions against diverse HPV types.
Ključne besede:surfactant protein A, SP-A, human papillomavirus, HPV, pseudovirus, cervical cancer, HPV prophylactic, low- and middle-income countries, LMIC
Status publikacije:Objavljeno
Verzija publikacije:Objavljena publikacija
Datum objave:01.01.2024
Leto izida:2024
Št. strani:str. 1-22
Številčenje:Vol. 25, issue 14, [article no.] 7712
PID:20.500.12556/RUNG-9196 Novo okno
COBISS.SI-ID:202458371 Novo okno
UDK:54
ISSN pri članku:1422-0067
eISSN:1422-0067
DOI:10.3390/ijms25147712 Novo okno
NUK URN:URN:SI:UNG:REP:Y1ZZ8AGC
Datum objave v RUNG:22.07.2024
Število ogledov:758
Število prenosov:7
Metapodatki:XML DC-XML DC-RDF
:
Kopiraj citat
  
Skupna ocena:(0 glasov)
Vaša ocena:Ocenjevanje je dovoljeno samo prijavljenim uporabnikom.
Objavi na:Bookmark and Share


Postavite miškin kazalec na naslov za izpis povzetka. Klik na naslov izpiše podrobnosti ali sproži prenos.

Gradivo je del revije

Naslov:International journal of molecular sciences
Skrajšan naslov:Int. j. mol. sci.
Založnik:MDPI
ISSN:1422-0067
COBISS.SI-ID:2779162 Novo okno

Gradivo je financirano iz projekta

Financer:ARIS - Javna agencija za znanstvenoraziskovalno in inovacijsko dejavnost Republike Slovenije
Program financ.:Raziskovalni projekt
Številka projekta:J3-2518
Naslov:Proteini APOBEC in onkogeneza virusov HPV

Licence

Licenca:CC BY 4.0, Creative Commons Priznanje avtorstva 4.0 Mednarodna
Povezava:http://creativecommons.org/licenses/by/4.0/deed.sl
Opis:To je standardna licenca Creative Commons, ki daje uporabnikom največ možnosti za nadaljnjo uporabo dela, pri čemer morajo navesti avtorja.
Začetek licenciranja:14.07.2024

Nazaj