111. The relationship between exhaled volatile organic compounds and lung function change in idiopathic pulmonary fibrosisConal Hayton, Waqar Ahmed, Dayle Terrington, Iain R. White, Nazia Chaudhuri, Colm Leonard, Andrew M. Wilson, Stephen J. Fowler, 2025, original scientific article Abstract: Volatile organic compounds (VOCs) in exhaled breath have shown promise as biomarkers in idiopathic pulmonary fibrosis (IPF). We analysed breath from 57 people with IPF using thermal desorption–gas chromatography–mass spectrometry to identify VOCs related to lung function change over 12 months. A LASSO regression model selected 63 VOCs associated with relative change in forced vital capacity (8 with correlation coefficient (CC) ≥0.20 on Spearman’s rank analysis), and 28 associated with relative change in diffusion capacity of the lung for carbon monoxide % predicted (12 with CC ≥0.20). Secondary analyses demonstrated a correlation between VOCs and baseline lung function parameters and association with survival. This study suggests that there may be a volatile signature of prognosis in IPF that merits further validation.
Keywords: idiopathic pulmonary fibrosis, volatile organic compound, thermal desorption mass spectrometry, exhaled breath
Published in RUNG: 13.05.2025; Views: 454; Downloads: 8
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116. Scalar diversity and second-language processing of scalar inferences : a cross-linguistic analysisGreta Mazzaggio, Federica Longo, Penka Stateva, Bob Van Tiel, 2025, original scientific article Abstract: We investigate the processing of scalar inferences in first language (L1) and second language (L2). Expanding beyond the common focus on the scalar inference from ‘some’ to ‘not all’, we examine six scalar expressions: ‘low’, ‘scarce’, ‘might’, ‘some’, ‘most’ and ‘try’. An online sentence-picture verification task was used to measure the frequency and time course of scalar inferences for these expressions. Participants included native English speakers, native Slovenian speakers and Slovenian speakers who spoke English as their L2. The first two groups were tested in their L1, while the third group was tested in their L2. Results showed that the English-L2 group resembled the Slovenian-L1 group more than the English-L1 group in terms of inference frequency. The time course for scalar inference computation was similar across all groups. These findings suggest subtle pragmatic transfer effects from L1 to L2, varying across different scalar expressions.
Keywords: scalar inference, conversational implicature, scalar diversity, second language, linguistic transfer, pragmatics, Slovenian
Published in RUNG: 07.05.2025; Views: 538; Downloads: 2
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117. The distribution of ultrahigh-energy cosmic rays along the supergalactic plane measured at the Pierre Auger ObservatoryA. Abdul Halim, P. Abreu, M. Aglietta, Andrej Filipčič, Jon Paul Lundquist, Shima Ujjani Shivashankara, Samo Stanič, Serguei Vorobiov, Danilo Zavrtanik, Marko Zavrtanik, 2025, original scientific article Abstract: Ultrahigh-energy cosmic rays are known to be mainly of extragalactic origin, and their propagation is limited by energy losses, so their arrival directions are expected to correlate with the large-scale structure of the local Universe. In this work, we investigate the possible presence of intermediate-scale excesses in the flux of the most energetic cosmic rays from the direction of the supergalactic plane region using events with energies above 20 EeV recorded with the surface detector array of the Pierre Auger Observatory up to 2022 December 31, with a total exposure of 135,000 sq. km sr yr. The strongest indication for an excess that we find, with a posttrial significance of 3.1σ, is in the Centaurus region, as in our previous reports, and it extends down to lower energies than previously studied. We do not find any strong hints of excesses from any other region of the supergalactic plane at the same angular scale. In particular, our results do not confirm the reports by the Telescope Array Collaboration of excesses from two regions in the Northern Hemisphere at the edge of the field of view of the Pierre Auger Observatory. With a comparable integrated exposure over these regions, our results there are in good agreement with the expectations from an isotropic distribution.
Keywords: ultra-high-energy cosmic rays, UHECR propagation, large-scale structure, UHECR energy losses, UHECR deflections, supergalactic plane region, Centaurus region, Pierre Auger Observatory, Auger surface detector array
Published in RUNG: 06.05.2025; Views: 603; Downloads: 5
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119. The Barcelona Raman LIDAR project and its prospects for the CTAO-NorthDarko Kolar, Otger Ballester, O. Blanch Bigas, Joan Boix, Paolo G. Calisse, Anna Campoy-Ordaz, Michele Doro, Samo Stanič, Marko Zavrtanik, Miha Živec, 2025, published scientific conference contribution Abstract: The Cherenkov Telescope Array Observatory (CTAO) is a next-generation facility comprised of ground-based Imaging Atmospheric Cherenkov Telescopes (IACTs). The observatory, currently under construction, will include more than 70 telescopes at two locations: in the northern hemisphere, CTAO-North at the Observatorio del Roque de Los Muchachos (ORM), La Palma, Canary Islands, Spain, and in the southern hemisphere, CTAO-South at a site belonging to the European Southern Observatory (ESO), Cerro Paranal, Chile. IACTs indirectly detect high-energy cosmic photons in an energy range from tens of GeV to several hundreds of TeV by measuring Cherenkov light emitted by atmospheric showers of secondary particles, produced through interactions between incident photons and nuclei of atmospheric gasses in the upper layers. The size of the CTAO will improve the detection sensitivity in the designed energy range by about an order of magnitude with respect to present experiments and aim at improved energy and angular resolution, as well as greatly reduced systematic uncertainties. The key to achieving improvements in accuracy on the absolute energy and flux scales is the precise monitoring of the atmospheric properties for the Cherenkov light, which can be obtained with a specifically designed LIDAR. The Barcelona Raman LIDAR (BRL) prototype is the official CTAO-North Pathfinder and was deployed at ORM for extensive tests between February 2021 and May 2022. We report the BRL’s prospects for the CTAO-North, emphasizing the technical implementation and the preliminary data taken during its deployment period.
Keywords: Cherenkov Telescope Array Observatory, CTAO, LIDAR, Barcelona Raman LIDAR
Published in RUNG: 05.05.2025; Views: 606; Downloads: 1
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120. Update on full-sky searches for large- and medium-scale anisotropies in the UHECR flux using the Pierre Auger Observatory and the Telescope ArrayGrigory I. Rubtsov, Andrej Filipčič, Jon Paul Lundquist, Shima Ujjani Shivashankara, Samo Stanič, Serguei Vorobiov, Danilo Zavrtanik, Marko Zavrtanik, 2025, published scientific conference contribution Abstract: The flux of ultra-high-energy cosmic rays (UHECRs) is remarkably uniform across all directions in the sky. The only anisotropy detected with a significance greater than 5σ is a large-scale dipolar modulation in right ascension for energies above 8 EeV. To enhance our sensitivity to potential anisotropies, which may be obscured by significant deflections by magnetic fields, two strategies can be employed: (1) focusing on large-scale anisotropies, such as the dipole and quadrupole moments across various energy intervals, which are anticipated to be more resilient to magnetic deflections; or (2) focusing on the highest energies, where the background from distant sources is more attenuated. The unique aspect of our research is achieving full-sky coverage by combining data for the Pierre Auger Observatory and the Telescope Array, which would not be possible with a single detector array. This comprehensive coverage enables the application of analysis techniques that would otherwise require specific assumptions with partial sky coverage. Accounting for potential systematic effects in energy reconstruction is crucial to avoid spurious north–south anisotropies; the overlapping sky region observed by both arrays allows us to address this in an entirely data-driven manner. In this contribution, we present the latest results using the largest UHECR dataset collected to date, with events detected until December 2022 at the Pierre Auger Observatory and until May 2024 at the Telescope Array. It is shown that the dipolar modulation is the only anisotropy that is significantly (4.6σ) identified in the angular power spectrum. The hypothesis of correlations with the starburst galaxies is supported at the significance of 4.4σ.
Keywords: ultra-high-energy cosmic rays, Pierre Auger Observatory, UHECR arrival directions, UHECR large-scale anisotropies, UHECR medium-scale anisotropies, full-sky coverage, Telescope Array
Published in RUNG: 05.05.2025; Views: 559; Downloads: 6
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