1. A porous organic polymer for synergistic light-triggered NO release and anticancer drug delivery : lecture at the iCeMS Retreat 2024, Kobe, Japan, 4. 7. 2024Tina Škorjanc, 2024, prispevek na konferenci brez natisa Opis: Treatment of biologically complex diseases, such as cancer, can significantly benefit from combination therapies. These powerful therapies are able to simultaneously target different biological targets, thereby overcoming or reducing drug resistance, decreasing dose-related toxicity, and potentially exhibiting synergistic effects. Herein, we combine the effects of nitric oxide (NO) gas therapy and an anticancer drug Doxorubicin (Dox) using a porous organic polymer (POP) as a delivery vehicle for both. SH-POP, synthesized by a facile, room-temperature method, is rich in both thiol (-SH) and secondary amine (R-NH-R’) functional groups, which can be post-synthetically nitrosylated in a room-temperature reaction that uses water as a solvent, yielding SNO-POP. Fourier-transform infrared (FT-IR) and Raman spectroscopy confirm that both types of functional groups are nitrosylated. Upon white light irradiation, SNO-POP releases up to ~60 µmol of NO per g, and exhibits reversible switch on – switch off NO release behavior triggered by simple light irradiation for at least 20 cycles. Unlike many conventional systems, where a known small-molecule NO donor is incorporated into the pores, here, the porous polymer itself serves as a NO donor, so the pores remain available for the encapsulation of another therapeutic, i.e. Dox. The release of Dox from the Dox@SNO-POP system is pH-sensitive and occurs preferentially in a slightly acidic environment (pH = 5.4). HeLa cancer cell viability studies confirm an enhancement in toxicity that can be ascribed to the synergistic effects of light-triggered NO release and pH-triggered Dox release. Confocal microscopy imaging reveals the presence of both species inside cells. This study is expected to stimulate the development of porous polymers as potent vehicles for combination therapies in cancer treatment and beyond.
Ključne besede: porous organic polymer, nitric oxide, combination therapy, synergistic therapy, chemotherapy
Objavljeno v RUNG: 05.07.2024; Ogledov: 10; Prenosov: 0
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2. Drought and temperature interaction on leaf hydraulic traits in grapevineElena Farolfi, Jan Reščič, Jacobs Spencer Harrison, Astrid Forneck, Jose Carlos Herrera, 2022, objavljeni povzetek znanstvenega prispevka na konferenci Opis: Global warming and increased frequency and/or severity of drought events are among the most
threatening consequences of climate change for agricultural crops. Understanding the mechanisms of
plant responses to both stressors is pivotal to successfully implement management strategies. Here
we explored the effect of temperature on the development of grapevine leaves with particular focus
on hydraulic traits under well-watered and water deficit conditions. We grew grafted grapevine (Vitis
vinifera L. cv. Pinot noir) in two different greenhouse chambers (20/15°C vs 25/20°C day/night) and
monitored their gas exchange, leaf size, stomatal density, chlorophyll fluorescence, pressure-volume
(PV) curves, osmotic potential and petiole xylem anatomy. PV curves provided clear evidence that
both, temperature and water availability, strongly affected the turgor loss point (TLP) as well as the
connected physiological traits. Leaves developing at higher temperature exhibited a more conservative
behaviour characterised by a lower gs max and a tighter stomatal closure in response to drought. The
study further discusses the results considering the coordination of traits changing in tandem and
implications in the face of climate change.
Key message: The ambient temperature at which leaves develop impacts on its hydraulic traits and
therefore on their successive response to drought
Ključne besede: drought, temperature, grapevine, xylem
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8. Raziskovalni podatki korpusa slovenskih kriminalk Sergeja Verča, Toneta Freliha, Avgusta Demšarja, Tadeja Goloba, Mojce Širok in Irene Svetek s perspektivi spola, etničnosti in razredaPrimož Mlačnik, 2024, zaključena znanstvena zbirka raziskovalnih podatkov Opis: Dani raziskovalni podatki so del večletne sistematične raziskave, v kateri je avtor analiziral serijske in sodobne slovenske kriminalke s perspektiv kulturnih študij. Raziskava je izhajala iz študij reprezentacij, ki prek analize ponavljajočih se reprezentacij (seksualnosti, spola, etničnosti in razreda) reflektirajo prevladujoče reprezentacijske režime (konservativne, liberalne ali kritične) in njihovo politiko reprezentacij. Avtor raziskave je v svojem preteklem raziskovalnem delu ugotovil, da so v omenjenih romanih identitete likov morilcev in žrtev prevladujoče zaznamovane s seksualnimi konotacijami (samskost, prešuštvo, homoseksualnost, promiskuiteta, ločenost, vdovstvo), ki se ne umeščajo v simbolni imaginarij heteronormativne monogamne partnerske zveze. Eden od ciljev raziskave je bil ugotoviti, kako se v analiziranem korpusu petintridesetih romanih šestih sodobnih slovenskih pisateljev in pisateljic serijskih kriminalnih romanov (Tone Frelih, Sergej Verč, Avgust Demšar, Tadej Golob, Irena Svetek in Mojca Širok) seksualno neheteronormativne/ali družbeno nesprejemljive seksualne konotacije likov detektivov, morilcev, žrtev in lažnih osumljencev povezujejo z drugimi identitetnimi označevalci – s spolom, razredom in etničnostjo. Raziskovalni podatki obsegajo petintrideset dekonstrukcijskih tabel v slovenskem in angleškem jeziku. Raziskava ni bila financirana
Ključne besede: Sodobni slovenski serijski kriminalni romani, reprezentacije spola, reprezentacije etničnosti, reprezentacije razreda
Objavljeno v RUNG: 02.07.2024; Ogledov: 103; Prenosov: 1
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9. Back to the future with emerging iron technologiesAndreea Oarga-Mulec, Uroš Luin, Matjaž Valant, 2024, pregledni znanstveni članek Opis: Here is a comprehensive overview of iron's potential in low-carbon energy technologies, exploring applications like metal fuel combustion, iron-based batteries, and energy-carrier cycles, as well as sustainable approaches for production and recycling with a focus on reducing environmental impact. Iron, with its abundance, safety, and electrochemical characteristics, is a promising material to contribute to a decarbonized future. This paper discusses the advancements and challenges in iron-based energy storage technologies and sustainable iron production methods. Various innovative approaches are explored as energy storage solutions based on iron, like advancements in thermochemical Fe–Cl cycles highlight the potential of iron chloride electrochemical cycles for long-term high-capacity energy storage technology. Additionally, the utilization of iron as a circular fuel in industrial processes demonstrates its potential in large-scale thermal energy generation. Sustainable iron production methods, such as electrolysis of iron chloride or oxide and deep eutectic solvent extraction, are investigated to reduce the carbon footprint in the iron and steel industry. These findings also show the importance of policy and technology improvements that are vital for the widespread use and recycling of iron-based tech, stressing the need for collaboration toward a sustainable future.
Ključne besede: iron's potential, low-carbon energy technologies
Objavljeno v RUNG: 02.07.2024; Ogledov: 95; Prenosov: 0
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10. Disruptive avant-garde art of today : shaping post-growth imaginaries for symbiotic futuresKristina Pranjić, Magdalena Germek, Peter Purg, 2024, objavljeni znanstveni prispevek na konferenci Ključne besede: imaginary, conviviality, symbiosis, cosmopolitics, defuturing, posthumanities, intermedia art
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