Iskanje po repozitoriju

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Ključne besede: topological insulator, platinum, interface, thin film, TEM, intermetallic
Objavljeno v RUNG: 28.01.2025; Ogledov: 421; Prenosov: 5
Celotno besedilo (6,19 MB)
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Ključne besede: naglasno mesto, izkorenske tvorjenke, izkategorialne tvorjenke, besedotvorna obrazila kot koreni, razpršena morfologija, slovenščina, zbirke podatkov
Objavljeno v RUNG: 27.01.2025; Ogledov: 462; Prenosov: 11
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Opis: The Zimm-Bragg (ZB) model serves as a fundamental framework for elucidating conformational transitions in biopolymers, offering simplicity and efficacy in processing experimental data. This study provides a comprehensive review of the Zimm-Bragg model and its Hamiltonian formulation, with particular emphasis on incorporating water interactions and chain size effects into the computational framework. We propose a modified ZB model that accounts for water-polypeptide interactions, demonstrating its ability to describe phenomena such as cold denaturation and helix-coil transitions. In the realm of NanoBioTechnologies, the manipulation of short polypeptide chains is commonplace. Experimental investigation of these chains in vitro often relies on techniques like Circular Dichroism (CD) and timeresolved infrared spectroscopy. Determining interaction parameters necessitates processing the temperature dependence of the normalized degree of helicity through model fitting. Leveraging recent advancements in the Hamiltonian formulation of the Zimm and Bragg model, we explicitly incorporate chain length and solvent effects into the theoretical description. The resulting expression for helicity degree adeptly fits experimental data, yielding hydrogen bonding energies and nucleation parameter values consistent with field standards. Differential Scanning Calorimetry (DSC) stands as a potent tool for measuring the specific heat profile of materials, including proteins. However, relating the measured profile to microscopic properties requires a suitable model for fitting. We propose a novel algorithm for processing DSC experimental data based on the ZB theory of protein folding in water. This approach complements the classical two-state paradigm and provides insights into protein-water and intraprotein hydrogen bonding energies. An analytical expression for heat capacity, considering water interaction, is derived and successfully applied to fit numerous DSC experimental datasets reported in the literature. Additionally, we compare this approach with the classical two-state model, demonstrating its efficacy in fitting DSC data. Furthermore, we have developed and launched a free online tool for processing CD and DSC experimental data related to protein folding, aiming to support scientific research.
Ključne besede: Zimm-Bragg model, conformational transitions, helix-coil transitions, cold denaturation, circular dichroism, differential scanning calorimetry, protein folding, water-protein interaction, hydrogen bonding energy, degree of helicity, short polypeptide chains, protein heat capacity, protein data analysis, dissertations
Objavljeno v RUNG: 27.01.2025; Ogledov: 435; Prenosov: 10
Celotno besedilo (5,12 MB)

Opis: Z dr. Kristino Glojek se pogovarjava o njenem večmesečnem merjenju zraka v idilični slovenski vasi, kamor si sredi zime meščani tako želimo, da bi zadihali s polnimi pljuči. Izkazalo se je, da je zrak prav tako onesnažen. Kako lahko pride do česa takega in kaj lahko storimo, pa v tem podkastu.
Ključne besede: onesnaženost zraka, podeželje, Slovenija
Objavljeno v RUNG: 24.01.2025; Ogledov: 450; Prenosov: 6
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Opis: Sedem milijonov ljudi na leto umre zaradi onesnaženega zraka. V Evropi je okoli 239 000 smrti mogoče pripisati posledicam izpostavljenosti delcem PM2,5. Kakšne so razmere v Sloveniji in kateri so glavni vzroki, da je zrak tako močno onesnažen? O tem v tokratnem Globusu.
Ključne besede: Onesnaženost zraka, Slovenija, Svet
Objavljeno v RUNG: 24.01.2025; Ogledov: 417; Prenosov: 2
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