1. Novel bispecific nanobody mitigates experimental intestinal inflammation in mice by targeting TNF-▫$\alpha$▫ and IL-23p19 bioactivitiesJiewen Wang, Guangbo Kang, Huiying Lu, Ario De Marco, Haibin Yuan, Zelin Feng, Mengxue Gao, Xiaoli Wang, Huahong Wang, Xiaolan Zhang, 2024, original scientific article Keywords: bispecific constructs, nanobodies, intestinal inflammation Published in RUNG: 27.03.2024; Views: 322; Downloads: 3 Full text (12,21 MB) This document has many files! More... |
2. Cosmic-ray Heavy Nuclei Spectra Using the ISS-CREAM InstrumentS.C. Kang, Jon Paul Lundquist, 2022, published scientific conference contribution Abstract: Cosmic Ray Energetics And Mass for the International Space Station (ISS-CREAM) was designed to study high-energy cosmic rays up to PeV and recorded data from August 22nd, 2017 to February 12th, 2019 on the ISS. In this analysis, the Silicon Charge Detector (SCD), CALorimeter (CAL), and Top and Bottom Counting Detectors (TCD/BCD) are used. The SCD is composed of four layers and provides the measurement of cosmic-ray charges with a resolution of ∼0.2e. The CAL comprises 20 interleaved tungsten plates and scintillators, measures the incident cosmic-ray particles' energies, and provides a high energy trigger. The TCD/BCDs consist of photodiode arrays and plastic scintillators and provide a low-energy trigger. In this analysis, the SCD top layer is used for charge determination. Here, we present the heavy nuclei analysis using the ISS-CREAM instrument. Keywords: ISS-CREAM, silicon charge detector, calorimeter, direct detection, heavy nuclei, cosmic rays, energy spectrum, composition Published in RUNG: 26.09.2023; Views: 628; Downloads: 5 Full text (1,82 MB) This document has many files! More... |
3. Affinity maturation of antibody fragments : a review encompassing the development from random approaches to computational rational optimizationJiaqi Liu, Guangbo Kang, Jiewen Wang, Haibin Yuan, Yili Wu, Shuxian Meng, Ping Wang, Miao Zhang, Yuli Wang, Yuanhang Feng, He Huang, Ario De Marco, 2023, review article Keywords: deep learning, protein modeling, random mutagenesis, rational mutagenesis Published in RUNG: 17.07.2023; Views: 855; Downloads: 4 Full text (2,21 MB) |
4. ŁUKASIEWICZ ANTI FUZZY SUBALGEBRAS OF BCK/BCI-ALGEBRASJeong Gi Kang, Hashem Bordbar, 2025, original scientific article Abstract: Abstract. The subalgebra of BCK/BCI-algebra using Łukasiewicz anti fuzzy set
introduced by Jun is studied in this article. The concept of Łukasiewicz anti
fuzzy subalgebra of a BCK/BCI-algebra is introduced, and several properties are
investigated. The relationship between anti fuzzy subalgebra and Łukasiewicz anti
fuzzy subalgebra is given, and the characterization of a Łukasiewicz anti fuzzy subalgebra
is discussed. Conditions are found in which a Lukasiewicz anti fuzzy set is a
Lukasiewicz anti fuzzy subalgebra Finally, conditions under which ⋖-subset, Υ- subset, and anti-subset become subalgebra are explored. Keywords: Anti fuzzy subalgebra, Łukasiewicz anti fuzzy set, Łukasiewicz anti fuzzy subalgebra, ⋖-subset, Υ-subset, anti subset Published in RUNG: 20.02.2023; Views: 923; Downloads: 0 This document has many files! More... |
5. Design of nanobody-based bispecific constructs by in silico affinity maturation and umbrella sampling simulationsZixuan Bai, Jiewen Wang, Jiaqi Liu, Haibin Yuan, Ping Wang, Miao Zhang, Yuanhang Feng, Xiangtong Cao, Xiangan Cao, Guangbo Kang, Ario De Marco, He Huang, 2023, original scientific article Keywords: nanobody rational design, bispecific binders, protein activity inhibition Published in RUNG: 03.01.2023; Views: 1171; Downloads: 3 Full text (8,75 MB) This document has many files! More... |
6. Research progress and applications of multivalent, multispecific and modified nanobodies for disease treatmentJiewen Wang, Guangbo Kang, Haibin Yuan, Xiaocang Cao, He Huang, Ario De Marco, 2022, original scientific article Keywords: nanobody multimers, immunomodulation, intrabodies, imaging, nanobody functionalization Published in RUNG: 18.01.2022; Views: 1740; Downloads: 154 Link to full text This document has many files! More... |
7. e/p separation study using the ISS-CREAM top and bottom counting detectorsS. C. Kang, Y. Amarea, D. Angelaszek, N. Anthony, G. H. Choi, M. Chung, M. Copley, L. Derome, L. Eraud, C. Falana, Jon Paul Lundquist, 2019, published scientific conference contribution Abstract: Cosmic Ray Energetics And Mass for the International Space Station (ISS-CREAM) is an experiment for studying the origin, acceleration, and propagation mechanisms of high-energy cosmic rays. The ISS-CREAM instrument was launched on the 14th of August 2017 to the ISS aboard the SpaceX-12 Dragon spacecraft. The Top and Bottom Counting Detectors (TCD/BCD) are parts of the ISS-CREAM instrument and designed for studying electron and gamma-ray physics. The TCD/BCD each consist of an array of 20 × 20 photodiodes on a plastic scintillator. The TCD/BCD can separate electrons from protons by using the difference between the shapes of electromagnetic and hadronic showers in the high energy region. The Boosted Decision Tree (BDT) method, which is a deep learning method, is used in this separation study. We will present results of the electron/proton separation study and rejection power in various energy ranges. Keywords: instrumentations, high energy cosmic rays, particle detectors, composition Published in RUNG: 08.02.2021; Views: 2275; Downloads: 0 This document has many files! More... |
8. On-orbit performance of the top and bottom counting detectors for the ISS-CREAM experiment on the international space stationS.C. Kang, Jon Paul Lundquist, 2019, original scientific article Abstract: The Cosmic Ray Energetics And Mass (CREAM) instrument on the International Space Station (ISS) is an experiment to study origin, propagation, acceleration and elemental composition of cosmic rays. The Top Counting Detector (TCD) and Bottom Counting Detector (BCD) are parts of the detector suite of the ISS-CREAM experiment and are designed to separate electrons and protons for studying electron and gamma-ray physics. In addition, the TCD/BCD provide a redundant trigger to that of the calorimeter and a low energy trigger to the ISS-CREAM instrument. After launching, the TCD/BCD trigger was found to be working well. Also, the TCD/BCD have been stable and their hit positions were confirmed to be well matched with other detectors on board. We present the performance and status of the TCD/BCD in flight. Keywords: ISS-CREAM, CREAM, Cosmic rays, TCD/BCD Published in RUNG: 27.04.2020; Views: 2635; Downloads: 111 Full text (2,00 MB) |