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4693. Biogas production from brewery spent grain as a mono-substrate in a two-stage process composed of solid-state anaerobic digestion and granular biomass reactorsMario Panjicko, Gregor Drago Zupančič, Romana Marinšek-Logar, Lijana Fanedl, Marina Tišma, Bruno Zelić, 2017, original scientific article Abstract: Anaerobic digestion of brewery spent grain as a mono-substrate was studied. Brewery spent grain is a substrate consisting largely of cellulose, hemicellulose and lignin, which are difficult to degrade anaerobically, mostly due to the presence of degradation products, such as phenolic compounds, which cause process inhibition. Therefore, a two-stage system was used for anaerobic digestion. Anaerobic digestion was phase separated in a solid-state anaerobic digestion reactor, where microbiological hydrolysis and acidogenesis occurred and in a granular biomass reactor where mostly methanogenesis was performed. The overall process exhibited total solids degradation efficiency between 75.9 and 83.0 %. Average specific biogas production was 414±32 L/kg, whereas biomethane production was 224±34 L/kg of added total solids. Granular biomass after adaptation exhibited stable operation at substrate C/N ratios in range 0.16 – 4.68. p-cresol was present in concentrations up to 45 mg/L and during the process was successfully degraded by granular biomass. The excellent adaptability of granular biomass was confirmed by 68.2 % shift in bacterial and a 31.8 % shift in archaeal community structure in a granular biomass reactor. The structure of the bacterial community from granular biomass reactor and solid-state anaerobic digestion reactor remained 79.4 % similar at the end of the experiment, whereas archaeal community was only 31.6 % similar. The process exhibited stable operation for 198 days, which shows that brewery spent grain can be successfully anaerobically digested and used for biogas production.
Keywords: biogas production, brewery spent grain, C/N ratio, dry digestion, microbial biomass, solid-state anaerobic digestion
Published in RUNG: 18.08.2017; Views: 4397; Downloads: 0
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4694. Identification of clusters of rapid and slow decliners among subjects at risk for Alzheimer’s diseaseDragan Gamberger, Nada Lavrač, Shantanu Srivatsa, Rudolph E. Tanzi, Murali Doraiswamy, 2017, original scientific article Abstract: The heterogeneity of Alzheimer’s disease contributes to the high failure rate of prior clinical trials. We analyzed 5-year longitudinal outcomes and biomarker data from 562 subjects with mild cognitive impairment (MCI) from two national studies (ADNI) using a novel multilayer clustering algorithm. The algorithm identified homogenous clusters of MCI subjects with markedly different prognostic cognitive
trajectories. A cluster of 240 rapid decliners had 2-fold greater atrophy and progressed to dementia at almost 5 times the rate of a cluster of 184 slow decliners. A classifier for identifying rapid decliners in one study showed high sensitivity and specificity in the second study. Characterizing subgroups of at risk subjects, with diverse prognostic outcomes, may provide novel mechanistic insights and facilitate clinical trials of drugs to delay the onset of AD.
Keywords: Alzheimer's disease, Rapid decliners, Data clustering, Mild cognitive impairment
Published in RUNG: 17.08.2017; Views: 4308; Downloads: 350
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4695. Pokristjanjevanje pri Prešernu in Bevku : Domoljubne prvine in vrednote v Prešernovi pesnitvi Krst pri Savici in Bevkovi povesti Umirajoči bog TriglavZoran Božič, unpublished invited conference lecture Abstract: Obe besedili sta nastali v prelomnih trenutkih slovenske zgodovine: Prešernova pesnitev v času nemške politične, gospodarske in kulturne nadvlade in porajanja zahtev po združeni Sloveniji, Bevkova povest pa v času italijanskega fašizma in okupacije Primorske. Na prvi pogled Prešernova visoka romantična poezija in Bevkova prejkone trivialna povest razen tematike poganstva in krščanstva nimata nič skupnega, vendar pa gre v obeh primerih za prikrito sporočilo, pogojeno s cenzurnimi postopki tedanje oblasti, za obsodbo nasilnih tujih oblastnikov, za pozive k narodni enotnosti, za poudarjanje domoljubne zavesti in za odnos do narave, ki kot najvišjo vrednoto vzpostavlja tostranstvo in ne onostranstvo.
Pokristjanjevanje pri Prešernu in Bevku: Domoljubne prvine in vrednote v Prešernovi pesnitvi Krst pri Savici in Bevkovi povesti Umirajoči bog Triglav. Available from: https://www.researchgate.net/publication/318753737_Pokristjanjevanje_pri_Presernu_in_Bevku_ [accessed Aug 14, 2017].
Keywords: slovenska literatura, poezija, proza, romantika, socialni realizem, France Prešeren, France Bevk, krščanstvo, poganstvo, pokristjanjevanje, Kobarid, Bohinj, cenzura, prikrito sporočilo, Metternichov absolutizem, italijanski fašizem, domoljubje
Published in RUNG: 17.08.2017; Views: 4763; Downloads: 228
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4697. Vimentin Modulates Infectious Internalization of Human Papillomavirus 16 PseudovirionsGeorgia Schäfer, Lisa M. Graham, Dirk M. Lang, Melissa J. Blumenthal, Martina Bergant Marušič, Arieh A. Katz, 2017, original scientific article Keywords: HPV16, vimentin, pseudovirions, infectious internalization
Published in RUNG: 17.08.2017; Views: 4340; Downloads: 249
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