3351. Quantitative detection of Microcystis aeruginosa in fresh water using single domain antibodies (VHHs)Gbenga Folorunsho Oginni, Sandra Oloketuyi, Elisa Mazzega, Mladen Franko, Hanna Budasheva, Dorota Korte, Ario De Marco, published scientific conference contribution abstract Keywords: thermal lens spectrometry, nanobodies, fluobodies, cyanobacteria
Published in RUNG: 18.11.2019; Views: 3662; Downloads: 122
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3356. A compact nanobody-DNAzyme conjugate enables antigen detection and signal amplificationGiulio Bernardinelli, Sandra Oloketuyi, Franziska Werner, Elisa Mazzega, Bjorn Hogberg, Ario De Marco, 2020, original scientific article Keywords: DNAzyme, nanobodies, diagnostics, A. minutum
Published in RUNG: 10.11.2019; Views: 3390; Downloads: 0
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3358. Metabolic dysregulation in vitamin E and carnitine shuttle energy mechanisms associate with human frailtyNicholas Rattray, Drupad Trivedi, Yun Xu, Tarani Chandola, Caroline Johnson, Alan Marshall, Krisztina Mekli, Zahra Rattray, Gindo Tampubolon, Bram Vanhoutte, Iain R. White, Frederick Wu, Neil Pendleton, James Nazroo, Royston Goodacre, 2019, original scientific article Abstract: Global ageing poses a substantial economic burden on health and social care costs. Enabling a greater proportion of older people to stay healthy for longer is key to the future sustainability of health, social and economic policy. Frailty and associated decrease in resilience plays a central role in poor health in later life. In this study, we present a population level assessment of the metabolic phenotype associated with frailty. Analysis of serum from 1191 older individuals (aged between 56 and 84 years old) and subsequent longitudinal validation (on 786 subjects) was carried out using liquid and gas chromatography-mass spectrometry metabolomics and stratified across a frailty index designed to quantitatively summarize vulnerability. Through multivariate regression and network modelling and mROC modeling we identified 12 significant metabolites (including three tocotrienols and six carnitines) that differentiate frail and non-frail phenotypes. Our study provides evidence that the dysregulation of carnitine shuttle and vitamin E pathways play a role in the risk of frailty.
Keywords: metabolomics, frailty, ageing, LC-MS, serum
Published in RUNG: 08.11.2019; Views: 3348; Downloads: 90
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