Repository of University of Nova Gorica

Search the repository
A+ | A- | Help | SLO | ENG

Query: search in
search in
search in
search in
* old and bologna study programme

Options:
  Reset


171 - 180 / 348
First pagePrevious page14151617181920212223Next pageLast page
171.
The conformational plasticity of the selectivity filter methionines controls the in-cell Cu(I) uptake through the CTR1 transporter
Pavel Janoš, Jana Aupič, Sharon Ruthstein , Alessandra Magistrato, 2022, original scientific article

Abstract: Copper is a trace element vital to many cellular functions. Yet its abnormal levels are toxic to cells, provoking a variety of severe diseases. The high affinity copper transporter 1 (CTR1), being the main in-cell copper [Cu(I)] entry route, tightly regulates its cellular uptake via a still elusive mechanism. Here, all-atoms simulations unlock the molecular terms of Cu(I) transport in eukaryotes disclosing that the two methionine (Met) triads, forming the selectivity filter, play an unprecedented dual role both enabling selective Cu(I) transport and regulating its uptake rate thanks to an intimate coupling between the conformational plasticity of their bulky side chains and the number of bound Cu(I) ions. Namely, the Met residues act as a gate reducing the Cu(I) import rate when two ions simultaneously bind to CTR1. This may represent an elegant autoregulatory mechanism through which CTR1 protects the cells from excessively high, and hence toxic, in-cell Cu(I) levels. Overall, our outcomes resolve fundamental questions in CTR1 biology and open new windows of opportunity to tackle diseases associated with an imbalanced copper uptake.
Keywords: copper, membrane transporter, molecular dynamics, QM/MM, free energy
Published in RUNG: 15.09.2022; Views: 1274; Downloads: 0
This document has many files! More...

172.
173.
174.
175.
Carbon nanoparticles assisted energy transport mechanism in leaves: A thermal lens study
Mohanachandran Nair Sindhu Swapna, 2019, original scientific article

Abstract: In the world of increasing population and pollution due to carbon emissions, the research for effective utilization of futile diesel soot for fruitful applications has become a necessity for a sustainable development. The contribution to pollution from vehicles and industries due to the aging of engines has caused a crisis. Carbon nanoparticles (CNPs) have been the subject of interest because of their good physical, chemical, and biological properties. The present work investigates the role of CNPs produced by internal combustion engines on the energy transport mechanism among leaf pigments using the sensitive and nondestructive single beam thermal lens technique. The studies reveal the absorption changes by various chlorophyll pigments with the concentration of CNPs sprayed on the leaves. Though for low concentrations CNPs lower the photon absorbance by chlorophyll pigments, the effect gets reversed at higher concentrations. The variation of thermal diffusivity with CNP concentration and its role in the energy transport mechanism among chlorophyll pigments are also studied. It is found that CNP concentrations of 625-2500mg/l are good for better intra-pigment energy transport leading to increased rate of photosynthesis and plant yield and thereby helping in attaining food security. The variation of CNP assisted energy transport among leaf pigments on the production of nicotinamide adenine dinucleotide phosphate (NADPH) and carbohydrates is also studied with ultraviolet (UV) and near-infrared (NIR) spectroscopy.
Keywords: carbon nanoparticle, soot, energy transport, thermal lens, photosynthesis
Published in RUNG: 05.07.2022; Views: 1071; Downloads: 0
This document has many files! More...

176.
Studies of cosmic rays in our Galaxy with Cherenkov Telescope Array : diploma seminar
Zoja Rokavec, 2022, research project (high school)

Keywords: cosmic rays, cosmic PeVatrons, Cherenkov Telescope Array, very-high-energy gamma-rays
Published in RUNG: 15.06.2022; Views: 1262; Downloads: 0
This document has many files! More...

177.
Multi-messenger studies with the Pierre Auger Observatory
Lukas Zehrer, Andrej Filipčič, Gašper Kukec Mezek, Jon Paul Lundquist, Samo Stanič, Marta Trini, Serguei Vorobiov, Marko Zavrtanik, Danilo Zavrtanik, 2021, published scientific conference contribution

Abstract: Over the past decade the multi-messenger astrophysics has emerged as a distinct discipline, providing unique insights into the properties of high-energy phenomena in the Universe. The Pierre Auger Observatory, located in Malargüe, Argentina, is the world’s largest cosmic ray detector sensitive to photons, neutrinos, and hadrons at ultra-high energies. Using its data, stringent limits on photon and neutrino fluxes at EeV energies have been obtained. The collaboration uses the excellent angular resolution and the neutrino identification capabilities of the Observatory for follow-up studies of events detected in gravitational waves or other messengers, through cooperation with global multi-messenger networks. We present a science motivation together with an overview of the multi-messenger capabilities and results of the Pierre Auger Observatory.
Keywords: high-energy cosmic phenomena, multi-messenger astrophysical studies, cosmic rays, gamma-rays, neutrinos, Pierre Auger Observatory
Published in RUNG: 06.05.2022; Views: 1411; Downloads: 0
This document has many files! More...

178.
179.
180.
REGIONAL POTENTIAL FOR SUSTAINABLE ENERGY SUPPLY IN CROATIA : MASTER'S THESIS
Stefan Subotić, master's thesis

Abstract: The master thesis aims to find the optimal model for a new energy company that considers regional potential, supports sustainable development, and fits the circular economy concept in a region. The idea of sustainable development is crucial today when we have more city areas and less countryside around the globe. Increased global population, industrial trends and modern living style are some of the reasons why the burden on our environment is more significant than ever in the history of humanity. The idea is to launch the new company in the Croatian region Osijek-Baranja, which is less developed and not attractive to tourists. A newly established company will produce electric energy from renewable energy sources. The multi-criterion decision support methods were used to determine the optimal energy source between wind, biogas and sun. Results show that the biogas has the most significant sustainable potential in chosen boundary conditions. The cash flows and other economic indicators are shown for a farm of 500 milking cows in the chosen region as a source of biogas. The risk assessments method estimated the boundaries of the company success and adaptability to possible changes. One of the critical aspects of the project is the company's organizational structure, where a vertical hierarchy with a flexible and fluid, circular organization model with network culture was proposed. Clear communication about the project will help establish trust with the local community. Based on the biogas plant, the proposed company reduces biodegradable waste in the green energy production process. It is shown quantitatively that besides being economically sustainable, it also suits the region's potential, supports energy self-supply, and involves local people - it aims to the long-term sustainable growth of the region, rather than short-term capital growth.
Keywords: Circular economy, sustainable development, regional potential, renewable energy sources, company structure, communication
Published in RUNG: 18.02.2022; Views: 2384; Downloads: 64
.pdf Full text (2,75 MB)

Search done in 0.07 sec.
Back to top