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1.
Exhaled volatile organic compounds and respiratory disease : recent progress and future outlook
Maria Chiara Magnano, Waqar Ahmed, Ran Wang, Martina Bergant Marušič, Stephen J. Fowler, Iain R. White, 2024, review article

Abstract: The theoretical basis of eVOCs as biomarkers for respiratory disease diagnosis is described, followed by a review of the potential biomarkers that have been proposed as targets from in vitro studies. The utility of these targets is then discussed based on comparison with results from clinical breath studies. The current status of breath research is summarised for various diseases, with emphasis placed on quantitative and targeted studies. Potential for bias highlights several important concepts related to standardization, including practices adopted for compound identification, correction for background inspired VOC levels and computation of mixing ratios. The compiled results underline the need for targeted studies across different analytical platforms to understand how sampling and analytical factors impact eVOC quantification. The impact of environmental VOCs as confounders in breath analysis is discussed alongside the potential that eVOCs have as biomarkers of air pollution exposure and future perspectives on clinical breath sampling are provided.
Keywords: breath analysis, disease diagnosis, exhaled volatile organic compounds, respiratory disease, environmental exposure analysis, breath analysis
Published in RUNG: 06.05.2024; Views: 67; Downloads: 1
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2.
Thermal Lens Spectrometry: Still a Technique on the Horizon
Mingqiang Liu, Mladen Franko, 2016, published scientific conference contribution

Abstract: In this article the historical development of thermal lens spectrometry (TLS) is briefly reviewed for introduction. In continuation, the emphasis is on the recent progresses of TLS for measurements in ensembled sample cells and in microfluidic flow injection systems. Novel theories, instrumentations and their applications for high sample throughput environmental, chemical and biomedical analysis, particularly in micro space, are presented. Discussions are given on the limitations of present TLS systems, that open new horizons for future progress of this technique, which has already found place among routine techniques for chemical analysis. In the last part, proposals for the future development of TLS toward advanced applications in new research fields are presented.
Keywords: Thermal lens spectrometry, Microfluidic chip, Chemical analysis, Environmental monitoring, Biomedical assay
Published in RUNG: 17.05.2016; Views: 5042; Downloads: 0
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