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33. Depth of maximum of air-shower profiles at the Pierre Auger Observatory: Measurements above 10^17.2 eV and Composition ImplicationsJosé Bellido, Andrej Filipčič, Gašper Kukec Mezek, Ahmed Saleh, Samo Stanič, Marta Trini, Serguei Vorobiov, Lili Yang, Danilo Zavrtanik, Marko Zavrtanik, 2017, objavljeni znanstveni prispevek na konferenci Ključne besede: Pierre Auger Observatory, depth of maximum of air-shower, mass composition Objavljeno v RUNG: 16.02.2018; Ogledov: 3161; Prenosov: 143 Celotno besedilo (1,19 MB) |
34. Results from the Pierre Auger ObservatoryIvan De Mitri, Andrej Filipčič, Samo Stanič, Darko Veberič, Danilo Zavrtanik, Marko Zavrtanik, 2015, objavljeni znanstveni prispevek na konferenci Ključne besede: Pierre Auger Observatory, Ultra High Energy Cosmic Rays (UHECR), UHECR energy spectrum, UHECR mass composition Objavljeno v RUNG: 27.06.2017; Ogledov: 4181; Prenosov: 0 Gradivo ima več datotek! Več... |
35. Astroparticles at the High Energy Frontier: Results from the Pierre Auger ObservatoryGonzalo Parente, Andrej Filipčič, Ahmed Saleh, Samo Stanič, Darko Veberič, Serguei Vorobiov, Danilo Zavrtanik, Marko Zavrtanik, 2014, objavljeni znanstveni prispevek na konferenci Ključne besede: Pierre Auger Observatory, ultra-high energy cosmic rays (UHECR), UHECR energy spectrum, mass composition, anisotropies Objavljeno v RUNG: 20.06.2017; Ogledov: 4938; Prenosov: 0 Gradivo ima več datotek! Več... |
36. Auger HighlightsAntonella Castellina, Andrej Filipčič, Gašper Kukec Mezek, Ahmed Saleh, Samo Stanič, Marta Trini, Darko Veberič, Serguei Vorobiov, Lili Yang, Danilo Zavrtanik, Marko Zavrtanik, 2014, objavljeni znanstveni prispevek na konferenci Ključne besede: Pierre Auger Observatory, ultra high energy cosmic rays (UHECR), UHECR hybrid detection technique, UHECR energy spectrum, UHECR mass composition, UHECR arrival directions Objavljeno v RUNG: 20.06.2017; Ogledov: 5198; Prenosov: 395 Celotno besedilo (861,47 KB) |
37. Development and Validation of a High- Performance Liquid Chromatography– Tandem Mass Spectrometry Method for the Simultaneous Determination of Irinotecan and Its Main Metabolites in Human Plasma and Its Application in a Clinical Pharmacokinetic StudyBianca Posocco, Elisa Mazzega, Elena Marangon, Giuseppe Toffoli, 2015, izvirni znanstveni članek Opis: Irinotecan is currently used in several cancer regimens mainly in colorectal cancer (CRC). This drug has a narrow therapeutic range and treatment can lead to side effects, mainly neutropenia and diarrhea, frequently requiring discontinuing or lowering the drug dose. A wide inter-individual variability in irinotecan pharmacokinetic parameters and pharmacodynamics has been reported and associated to patients’ genetic background. In particular, a polymorphism in the UGT1A1 gene (UGT1A1*28) has been linked to an impaired detoxification of SN-38 (irinotecan active metabolite) to SN-38 glucuronide (SN-38G) leading to increased toxicities. Therefore, therapeutic drug monitoring of irinotecan, SN-38 and SN-38G is recommended to personalize therapy. In order to quantify simultaneously irinotecan and its main metabolites in patients’ plasma, we developed and validated a new, sensitive and specific HPLC–MS/MS method applicable to all irinotecan dosages used in clinic. This method required a small plasma volume, addition of camptothecin as internal standard and simple protein precipitation. Chromatographic separation was done on a Gemini C18 column (3 μM, 100 mm x 2.0 mm) using 0.1% acetic acid/bidistilled water and 0.1% acetic acid/acetonitrile as mobile phases. The mass spectrometer worked with electrospray ionization in positive ion mode and selected reaction monitoring. The standard curves were linear (R20.9962) over the concentration ranges (10–10000 ng/mL for irinotecan, 1–500 ng/mL for SN-38 and SN-38G and 1–5000 ng/mL for APC) and had good back-calculated accuracy and precision. The intra- and inter-day precision and accuracy, determined on three quality control levels for all the analytes, were always <12.3% and between 89.4% and 113.0%, respectively. Moreover, we evaluated this bioanalytical method by re-analysis of incurred samples as an additional measure of assay reproducibility. This method wassuccessfully applied to a pharmacokinetic study in metastatic CRC patients enrolled in a genotype-guided phase Ib study of irinotecan administered in combination with 5-fluorouracil/ leucovorin and bevacizumab. Ključne besede: Pharmacokinetic, pharmacodynamics, phase I clinical study, colorectal cancer, Mass spectrometry, pharmacogenetics Objavljeno v RUNG: 21.03.2017; Ogledov: 4617; Prenosov: 0 Gradivo ima več datotek! Več... |
38. Evidence for a mixed mass composition at the ‘ankle’ in the cosmic-ray spectrumA. Aab, Andrej Filipčič, Gašper Kukec Mezek, Ahmed Saleh, Samo Stanič, Marta Trini, Darko Veberič, Serguei Vorobiov, Lili Yang, Danilo Zavrtanik, Marko Zavrtanik, 2016, izvirni znanstveni članek Ključne besede: ultra-high energy cosmic rays (UHECR), UHECR mass composition, UHECR energy spectrum, Pierre Auger Observatory, composition studies at the ‘ankle’ region in the UHECR spectrum Objavljeno v RUNG: 25.11.2016; Ogledov: 4762; Prenosov: 180 Celotno besedilo (1,73 MB) |
39. Report of the Working Group on the Composition of Ultra High Energy Cosmic RaysR. Abbasi, Andrej Filipčič, Ahmed Saleh, Samo Stanič, Serguei Vorobiov, Danilo Zavrtanik, Marko Zavrtanik, 2016, objavljeni znanstveni prispevek na konferenci Ključne besede: ultra-high energy cosmic rays (UHECR), UHECR mass composition, Pierre Auger Observatory, Telescope Array, cross-calibration studies Objavljeno v RUNG: 17.11.2016; Ogledov: 5284; Prenosov: 0 Gradivo ima več datotek! Več... |
40. Measurement of the mass composition of ultra-high energy cosmic rays with the Pierre Auger ObservatoryMariangela Settimo, Andrej Filipčič, Gašper Kukec Mezek, Ahmed Saleh, Samo Stanič, Marta Trini, Darko Veberič, Serguei Vorobiov, Lili Yang, Danilo Zavrtanik, Marko Zavrtanik, 2016, objavljeni znanstveni prispevek na konferenci Ključne besede: ultra-high energy cosmic rays (UHECR), Pierre Auger Observatory, UHECR mass composition Objavljeno v RUNG: 09.11.2016; Ogledov: 4531; Prenosov: 236 Celotno besedilo (1,24 MB) |