| Title: | Circadian rhythm of exhaled biomarkers in health and asthma |
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| Authors: | ID Wilkinson, Max, Division of Infection, Immunity and Respiratory Medicine, School of Biological Sciences, Faculty of Biology, Medicine and Health, University of Manchester, Manchester, UK (Author)
ID Maidstone, Robert, NIHR Oxford Biomedical Research Centre, John Radcliffe Hospital, Oxford, UK and Oxford Centrefor Diabetes, Endocrinology and Metabolism, University of Oxford, Oxford, UK (Author)
ID Loudon, Andrew, Division of Diabetes, Endocrinology and Gastroenterology, School of Medical Sciences, Faculty of Biology, Medicine and Health, University of Manchester, UK (Author)
ID Blaikley, John, Manchester Academic Health Science Centre and NIHR Biomedical Research Centre, Manchester University Hospitals NHS Foundation Trust, UK (Author)
ID White, Iain R., Laboratory for Environmental and Life Sciences, University of Nova Gorica, Vipavska 13, SI-5000 Nova Gorica, Slovenia (Author)
ID Singh, Dave, Division of Infection, Immunity and Respiratory Medicine, School of Biological Sciences, Faculty of Biology, Medicine and Health, University of Manchester, Manchester, UK (Author)
ID Ray, David, Division of Informatics, Imaging and Data Sciences, School of Biological Sciences, Faculty of Biology, Medicine and Health, University of Manchester, UK (Author)
ID Goodacre, Royston, Department of Biochemistry, Institute of Integrative Biology, University of Liverpool, Biosciences Building, Crown Street, Liverpool L69 7ZB, UK (Author)
ID Fowler, Stephen, Manchester Academic Health Science Centre and NIHR Biomedical Research Centre, Manchester University Hospitals NHS FoundationTrust, UK (Author)
ID Durrington, Hannah, Division of Infection, Immunity and Respiratory Medicine, School of Biological Sciences, Faculty of Biology, Medicine and Health, University of Manchester, Manchester, UK (Author) |
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| Files: |
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| Language: | English |
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| Work type: | Not categorized |
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| Typology: | 1.01 - Original Scientific Article |
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| Organization: | UNG - University of Nova Gorica
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| Abstract: | Circadian rhythms control many biological processes in the body in both health and disease. Greater understanding of diurnal variability in disease related biomarkers is crucial for their application in clinical practice and biomarkers of circadian rhythm are required to facilitate further research into disturbed chronicity. To determine if fractional exhaled nitric oxide and breath volatile biomarkers vary rhythmically during the day in healthy and asthmatic individuals.
Ten individuals with moderate, atopic asthma (on regular inhaled corticosteroids) and 10 healthy volunteers (all non-smokers) completed an overnight visit where their exhaled breath volatiles and forced exhaled nitric oxide levels were collected every 6 h. Breath volatiles were analysed using gas chromatography mass spectrometry, after trapping these volatiles on sorbent materials for thermal desorption.
Nine breath volatiles (including acetone and isoprene) exhibit diurnal variation across all individuals. Furthermore the circadian pattern of several VOCs is altered in individuals with asthma and fractional exhaled nitric oxide is rhythmic in asthma but not in healthy controls.
Markers of circadian rhythm can be identified in breath and may offer insight into circadian profiling to help treat disease. Additionally this work suggests that time of day must be controlled when designing future biomarker discovery studies. Further work is required with larger cohorts to validate and extend these findings. |
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| Keywords: | VOCs, breath, asthma, circadian |
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| Publication version: | Author Accepted Manuscript |
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| Year of publishing: | 2019 |
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| Number of pages: | 4 |
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| Numbering: | 4, 54 |
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| PID: | 20.500.12556/RUNG-4799-7b09a68e-7000-2730-d5e6-5adeaca2d000 |
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| COBISS.SI-ID: | 5466107 |
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| DOI: | 10.1183/13993003.01068-2019 |
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| NUK URN: | URN:SI:UNG:REP:ZNHSLATV |
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| Publication date in RUNG: | 21.10.2019 |
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| Views: | 3264 |
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| Downloads: | 0 |
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