| Title: | Exhaled volatile organic compounds and respiratory disease : recent progress and future outlook |
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| Authors: | ID Magnano, Maria Chiara (Author)
ID Ahmed, Waqar (Author)
ID Wang, Ran (Author)
ID Bergant Marušič, Martina (Author)
ID Fowler, Stephen J. (Author)
ID White, Iain R. (Author) |
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| Files: |  1-s2.0-S016599362400222X-main.pdf (1,36 MB)
MD5: 26E6DCC9F6ED8797D00842F57383BE79
 https://authors.elsevier.com/sd/article/S0165-9936(24)00222-X
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| Language: | English |
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| Work type: | Unknown |
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| Typology: | 1.02 - Review Article |
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| Organization: | UNG - University of Nova Gorica
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| Abstract: | The theoretical basis of eVOCs as biomarkers for respiratory disease diagnosis is described, followed by a review of the potential biomarkers that have been proposed as targets from in vitro studies. The utility of these targets is then discussed based on comparison with results from clinical breath studies. The current status of breath research is summarised for various diseases, with emphasis placed on quantitative and targeted studies. Potential for bias highlights several important concepts related to standardization, including practices adopted for compound identification, correction for background inspired VOC levels and computation of mixing ratios. The compiled results underline the need for targeted studies across different analytical platforms to understand how sampling and analytical factors impact eVOC quantification. The impact of environmental VOCs as confounders in breath analysis is discussed alongside the potential that eVOCs have as biomarkers of air pollution exposure and future perspectives on clinical breath sampling are provided. |
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| Keywords: | breath analysis, disease diagnosis, exhaled volatile organic compounds, respiratory disease, environmental exposure analysis, breath analysis |
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| Publication status: | Published |
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| Publication version: | Version of Record |
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| Publication date: | 01.01.2024 |
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| Year of publishing: | 2024 |
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| Number of pages: | str. 1-14 |
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| Numbering: | Vol. 176, [article no.] ǂ117739 |
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| PID: | 20.500.12556/RUNG-9004-2f27ec28-a5c7-99f9-0251-426e60eacf8f  |
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| COBISS.SI-ID: | 194499075 |
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| UDC: | 543 |
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| ISSN on article: | 0165-9936 |
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| DOI: | 10.1016/j.trac.2024.117739 |
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| NUK URN: | URN:SI:UNG:REP:NQZP7MLW |
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| Publication date in RUNG: | 06.05.2024 |
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| Views: | 1347 |
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| Downloads: | 9 |
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