Repozitorij Univerze v Novi Gorici

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Naslov:Nanobodies against surface biomarkers enable the analysis of tumor genetic heterogeneity in uveal melanoma Patient Derived Xenografts
Avtorji:Crepin, Ronan (Avtor)
Gentien, David (Avtor)
Duche, Angeline (Avtor)
Rapinat, Audrey (Avtor)
Reyes, Cecile (Avtor)
Nemati, Fariba (Avtor)
Massonnet, Gerald (Avtor)
Deacaudin, Didier (Avtor)
Djander, Selma (Avtor)
Moutel, Sandrine (Avtor)
Desrumeaux, Klervi Even (Avtor)
Cassoux, Nathalie (Avtor)
Piperno-Neumann, Sophie (Avtor)
Amigorena, Sebastian (Avtor)
Perez, Franck (Avtor)
Roman-Roman, Sergio (Avtor)
de Marco, Ario (Avtor)
Datoteke:Gradivo nima datotek. Gradivo je morda fizično dosegljivo v knjižnici fakultete, zalogo lahko preverite v COBISS-u. Povezava se odpre v novem oknu
Jezik:Angleški jezik
Vrsta gradiva:Delo ni kategorizirano (r6)
Tipologija:1.01 - Izvirni znanstveni članek
Organizacija:UNG - Univerza v Novi Gorici
Opis:Monoclonal antibodies specific for biomarkers expressed on the surface of uveal melanoma (UM) cells would simplify the immune-capture and genomic characterization of heterogeneous tumor cells originated from patient derived xenografts (PDXs). Antibodies against four independent tumor antigens were isolated by panning a nanobody synthetic library. Such antibodies enabled flow-cytometry-based sorting of distinct cell sub-populations from UM PDXs and to analyze their genomic features. The complexity and specificity of the biochemical and genomic biomarker combinations mirrored the UM tumor polyclonality. The data showed that MUC18 is highly and universally displayed at the surface of UM cells with different genetic background and consequently represents a reliable pan-biomarker for their identification and purification. In contrast, the other three biomarkers were detected in very variable combinations in UM PDX cells. The availability of the identified nanobodies will be instrumental in developing clone-specific drug evaluation and rational clinical strategies based on accurate genomic profiling
Ključne besede:nanobodies, uveal melanoma, patient derived xenografts, MUC18, membrane surface biomarkers, panning, tumor polyclonality
Leto izida:2017
Št. strani:11
Številčenje:30
COBISS_ID:4768763 Povezava se odpre v novem oknu
DOI:10.1111/pcmr.12577 Povezava se odpre v novem oknu
Licenca:CC BY-NC-ND 4.0
To delo je dosegljivo pod licenco Creative Commons Priznanje avtorstva-Nekomercialno-Brez predelav 4.0 Mednarodna
Število ogledov:187
Število prenosov:0
Metapodatki:XML RDF-CHPDL DC-XML DC-RDF
Področja:Gradivo ni uvrščeno v področja.
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Skupna ocena:(0 glasov)
Vaša ocena:Ocenjevanje je dovoljeno samo prijavljenim uporabnikom.

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Gradivo je del revije

Naslov:Pigment Cell and Melanoma Research
Založnik:Wiley: 12 months
ISSN:1755-1471
Leto izida:2017

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