Repozitorij Univerze v Novi Gorici

Izpis gradiva
A+ | A- | SLO | ENG

Naslov:Metabolic dysregulation in vitamin E and carnitine shuttle energy mechanisms associate with human frailty
Avtorji:Rattray, Nicholas (Avtor)
Trivedi, Drupad (Avtor)
Xu, Yun (Avtor)
Chandola, Tarani (Avtor)
Johnson, Caroline (Avtor)
Marshall, Alan (Avtor)
Mekli, Krisztina (Avtor)
Rattray, Zahra (Avtor)
Tampubolon, Gindo (Avtor)
Vanhoutte, Bram (Avtor)
White, Iain (Avtor)
Wu, Frederick (Avtor)
Pendleton, Neil (Avtor)
Nazroo, James (Avtor)
Goodacre, Royston (Avtor)
Datoteke:.pdf s41467-019-12716-2.pdf (2,35 MB)
 
Jezik:Angleški jezik
Vrsta gradiva:Delo ni kategorizirano (r6)
Tipologija:1.01 - Izvirni znanstveni članek
Organizacija:UNG - Univerza v Novi Gorici
Opis:Global ageing poses a substantial economic burden on health and social care costs. Enabling a greater proportion of older people to stay healthy for longer is key to the future sustainability of health, social and economic policy. Frailty and associated decrease in resilience plays a central role in poor health in later life. In this study, we present a population level assessment of the metabolic phenotype associated with frailty. Analysis of serum from 1191 older individuals (aged between 56 and 84 years old) and subsequent longitudinal validation (on 786 subjects) was carried out using liquid and gas chromatography-mass spectrometry metabolomics and stratified across a frailty index designed to quantitatively summarize vulnerability. Through multivariate regression and network modelling and mROC modeling we identified 12 significant metabolites (including three tocotrienols and six carnitines) that differentiate frail and non-frail phenotypes. Our study provides evidence that the dysregulation of carnitine shuttle and vitamin E pathways play a role in the risk of frailty.
Ključne besede:metabolomics, frailty, ageing, LC-MS, serum
Leto izida:2019
Št. strani:12
Številčenje:10
COBISS_ID:5478907 Povezava se odpre v novem oknu
URN:URN:SI:UNG:REP:FJYX4KQN
DOI:doi:10.1038/s41467-019-12716-2 Povezava se odpre v novem oknu
Licenca:CC BY-NC-SA 4.0
To delo je dosegljivo pod licenco Creative Commons Priznanje avtorstva-Nekomercialno-Deljenje pod enakimi pogoji 4.0 Mednarodna
Število ogledov:66
Število prenosov:1
Metapodatki:XML RDF-CHPDL DC-XML DC-RDF
Področja:Gradivo ni uvrščeno v področja.
:
  
Skupna ocena:(0 glasov)
Vaša ocena:Ocenjevanje je dovoljeno samo prijavljenim uporabnikom.

Postavite miškin kazalec na naslov za izpis povzetka. Klik na naslov izpiše podrobnosti ali sproži prenos.

Gradivo je del revije

Naslov:Nature Communications
Založnik:Nature Publishing Group
ISSN:2041-1723
Leto izida:2019

Nazaj