Repozitorij Univerze v Novi Gorici

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Naslov:Circadian rhythm of exhaled biomarkers in health and asthma
Avtorji:Wilkinson, Max (Avtor)
Maidstone, Robert (Avtor)
Loudon, Andrew (Avtor)
Blaikley, John (Avtor)
White, Iain (Avtor)
Singh, Dave (Avtor)
Ray, David (Avtor)
Goodacre, Royston (Avtor)
Fowler, Stephen (Avtor)
Durrington, Hannah (Avtor)
Datoteke:Gradivo nima datotek. Gradivo je morda fizično dosegljivo v knjižnici fakultete, zalogo lahko preverite v COBISS-u. Povezava se odpre v novem oknu
Jezik:Angleški jezik
Vrsta gradiva:Delo ni kategorizirano (r6)
Tipologija:1.01 - Izvirni znanstveni članek
Organizacija:UNG - Univerza v Novi Gorici
Opis:Circadian rhythms control many biological processes in the body in both health and disease. Greater understanding of diurnal variability in disease related biomarkers is crucial for their application in clinical practice and biomarkers of circadian rhythm are required to facilitate further research into disturbed chronicity. To determine if fractional exhaled nitric oxide and breath volatile biomarkers vary rhythmically during the day in healthy and asthmatic individuals. Ten individuals with moderate, atopic asthma (on regular inhaled corticosteroids) and 10 healthy volunteers (all non-smokers) completed an overnight visit where their exhaled breath volatiles and forced exhaled nitric oxide levels were collected every 6 h. Breath volatiles were analysed using gas chromatography mass spectrometry, after trapping these volatiles on sorbent materials for thermal desorption. Nine breath volatiles (including acetone and isoprene) exhibit diurnal variation across all individuals. Furthermore the circadian pattern of several VOCs is altered in individuals with asthma and fractional exhaled nitric oxide is rhythmic in asthma but not in healthy controls. Markers of circadian rhythm can be identified in breath and may offer insight into circadian profiling to help treat disease. Additionally this work suggests that time of day must be controlled when designing future biomarker discovery studies. Further work is required with larger cohorts to validate and extend these findings.
Ključne besede:VOCs, breath, asthma, circadian
Leto izida:2019
Št. strani:4
Številčenje:54, 4
COBISS_ID:5466107 Povezava se odpre v novem oknu
URN:URN:SI:UNG:REP:ZNHSLATV
DOI:10.1183/13993003.01068-2019 Povezava se odpre v novem oknu
Licenca:CC BY-NC-SA 4.0
To delo je dosegljivo pod licenco Creative Commons Priznanje avtorstva-Nekomercialno-Deljenje pod enakimi pogoji 4.0 Mednarodna
Število ogledov:1459
Število prenosov:0
Metapodatki:XML RDF-CHPDL DC-XML DC-RDF
Področja:Gradivo ni uvrščeno v področja.
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Skupna ocena:(0 glasov)
Vaša ocena:Ocenjevanje je dovoljeno samo prijavljenim uporabnikom.

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Gradivo je del revije

Naslov:European Respiratory Journal
Skrajšan naslov:ERJ
Založnik:European Respiratory Society
ISSN:0903-1936
Leto izida:2019

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