1. Novel bispecific nanobody mitigates experimental intestinal inflammation in mice by targeting TNF-▫$\alpha$▫ and IL-23p19 bioactivitiesJiewen Wang, Guangbo Kang, Huiying Lu, Ario De Marco, Haibin Yuan, Zelin Feng, Mengxue Gao, Xiaoli Wang, Huahong Wang, Xiaolan Zhang, 2024, original scientific article Keywords: bispecific constructs, nanobodies, intestinal inflammation
Published in RUNG: 27.03.2024; Views: 1613; Downloads: 7
 Full text (12,21 MB)
This document has many files! More... |
2. Affinity maturation of antibody fragments : a review encompassing the development from random approaches to computational rational optimizationJiaqi Liu, Guangbo Kang, Jiewen Wang, Haibin Yuan, Yili Wu, Shuxian Meng, Ping Wang, Miao Zhang, Yuli Wang, Yuanhang Feng, He Huang, Ario De Marco, 2023, review article Keywords: deep learning, protein modeling, random mutagenesis, rational mutagenesis
Published in RUNG: 17.07.2023; Views: 1882; Downloads: 8
Full text (2,21 MB) |
3. Design of nanobody-based bispecific constructs by in silico affinity maturation and umbrella sampling simulationsZixuan Bai, Jiewen Wang, Jiaqi Liu, Haibin Yuan, Ping Wang, Miao Zhang, Yuanhang Feng, Xiangtong Cao, Xiangan Cao, Guangbo Kang, Ario De Marco, He Huang, 2023, original scientific article Keywords: nanobody rational design, bispecific binders, protein activity inhibition
Published in RUNG: 03.01.2023; Views: 2127; Downloads: 7
Full text (8,75 MB)
This document has many files! More... |
4. Research progress and applications of multivalent, multispecific and modified nanobodies for disease treatmentJiewen Wang, Guangbo Kang, Haibin Yuan, Xiaocang Cao, He Huang, Ario De Marco, 2022, original scientific article Keywords: nanobody multimers, immunomodulation, intrabodies, imaging, nanobody functionalization
Published in RUNG: 18.01.2022; Views: 2576; Downloads: 156
 Link to full text
This document has many files! More... |
5. Effect of Humanizing Mutations on the Stability of the Llama Single-Domain Variable RegionMiguel Soler, Barbara Medagli, Jiewen Wang, Sandra Oloketuyi, Gregor Bajc, He Huang, Sara Fortuna, Ario De Marco, 2021, original scientific article Keywords: nanobody framework, modeling, nanobody humanization, CDR grafting
Published in RUNG: 27.01.2021; Views: 3190; Downloads: 68
Full text (2,00 MB) |
