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Regulation and controlling the motility properties of Pseudomonas aeruginosa
Fazlurrahman Khan, Dung Thuy Nguyen Pham, Sandra Oloketuyi, Young-Mog Kim, 2020, review article

Abstract: Chronic infections caused by Pseudomonas aeruginosa have been a major concern as their spread and mortality continue to be on the rise. These infections are majorly attributed to biofilm formation via sequential steps where motility plays an essential role in initial attachment of bacterial cells onto biotic and abiotic surfaces, thereby contributing to multi-drug resistance among pathogens. Therefore, attenuating motility properties can be considered as highly potential for controlling P. aeruginosa biofilm formation. This strategy has employed the use of various natural and chemically synthesized compounds. The present review article explained the importance and regulation of different types of motilities properties. Furthermore, it also covered several important alternative approaches using anti-motility agents which could be helpful for controlling P. aeruginosa biofilm-associated infections. Further studies are required for in-depth understandings about the mechanisms of motilities controlling of these molecules at molecular levels.
Found in: ključnih besedah
Summary of found: ...Biofilm, Motility, Attenuation, Antibiofilm drugs, Pseudomonas aeruginosa...
Keywords: Biofilm, Motility, Attenuation, Antibiofilm drugs, Pseudomonas aeruginosa
Published: 12.01.2021; Views: 958; Downloads: 0
.pdf Fulltext (4,83 MB)

Chitosan and their derivatives: Antibiofilm drugs against pathogenic bacteria
Fazlurrahman Khan, Dong Pham, Sandra Oloketuyi, Panchanathan Manivasagan, Junghwan Oh, Young-Mog Kim, 2020, review article

Abstract: Biofilm formed by several pathogenic bacteria results in the development of resistance against antimicrobial compounds. The polymeric materials present in the biofilm architecture hinder the entry of antimicrobial compounds through the surface of bacterial cells which are embedded as well as enclosed beneath the biofilm matrix. Recent and past studies explored the alternative approaches to inhibit the formation of biofilm by different agents isolated from plants, animals, and microbes. Among these agents, chitosan and its derivatives have got more attention due to their properties such as biodegradability, biocompatibility, non-allergenic and non-toxicity. Recent researches have focused on employing chitosan and its derivatives as effective agents to inhibit biofilm formation and attenuate virulence properties by various pathogenic bacteria. Such antibiofilm activity of chitosan and its derivatives can be further enhanced by conjugation with a wide range of bioactive compounds. The present review describes the antibiofilm properties of chitosan and its derivatives against the pathogenic bacteria. This review also summarizes the mechanisms of biofilm inhibition exhibited by these molecules. The knowledge of the antibiofilm activities of chitosan and its derivatives as well as their underlying mechanisms provides essential insights for widening their applications in the future.
Found in: ključnih besedah
Keywords: Antibiofilm, Biofilm inhibition, Chitosan, Chitosan derivatives, Pathogenic bacteria
Published: 14.01.2021; Views: 849; Downloads: 0
.pdf Fulltext (3,95 MB)

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