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1.
A novel dual-cytokine-antibody fusion protein for the treatment of CD38-positive malignancies
Roberto De Luca, Paul Kachel, Klara Kropivšek, Berend Snijder, Markus G. Manz, Dario Neri, 2018, original scientific article

Abstract: A novel dual-cytokine–antibody fusion protein, consisting of an antibody directed against CD38 [a tumor-associated antigen mainly expressed on the surface of multiple myeloma (MM) cells], simultaneously fused to both tumor necrosis factor ligand superfamily member 10 (TRAIL) and interleukin-2 (IL2), was designed, expressed and purified to homogeneity. The novel fusion protein, termed IL2-αCD38-αCD38-scTRAIL, was able to selectively recognize its cognate antigen expressed on the surface of MM and lymphoma cell lines, as evidenced by flow cytometry analysis. Moreover, the targeted version of TRAIL was able to induce cancer cell death in vitro, both with MM cell lines and with fresh isolates from the bone marrow of MM patients. The experiments provide a rationale for possible future applications of IL2-αCD38-αCD38-scTRAIL for the treatment of patients with MM or other CD38-positive malignancies.
Keywords: antibodies, dual-cytokine-antibody, CD38, multiple myeloma, TRAIL, IL2
Published in RUNG: 11.11.2024; Views: 201; Downloads: 1
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2.
Does grammatical number support the acquisition of number words?
Anna Shusterman, Abigail Seevak, Petra Mišmaš, Franc Marušič, Rok Žaucer, 2023, published scientific conference contribution

Keywords: Slovenian, grammatical number, acquisition, number words, dual
Published in RUNG: 21.07.2023; Views: 1645; Downloads: 3
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3.
4.
Investigation of Slovenian copular agreement
Franc Marušič, Rok Žaucer, 2021, published scientific conference contribution

Abstract: This paper reports on a detailed investigation of agreement inside simple predicative sentences. In this type of sentence, both noun phrases are in the nominative, so in principle either one can trigger agreement on the copular verb. We examine various types of copular contructions and show that regardless of the type of predicative sentence, when a plural is combined with a singular, it is always the plural that agrees. Similarly, when a dual is combined with a singular, the dual wins out. But when we combine a dual and a plural, the copula can agree with either of the two noun phrases, with a preference for the noun phrase following the copula. We discuss the relevance of these findings for recent literature on predication.
Keywords: agreement, copula, number, singular, dual, plural, Slovenian
Published in RUNG: 31.01.2022; Views: 2438; Downloads: 0
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5.
Number in Slovenian Copular Clauses
Rok Žaucer, unpublished invited conference lecture

Keywords: number, dual, copular clauses, agreement, Slovenian
Published in RUNG: 23.09.2021; Views: 2412; Downloads: 0
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6.
Dual in Slovenian
Franc Marušič, Rok Žaucer, 2021, independent scientific component part or a chapter in a monograph

Abstract: Slovenian is one of only three contemporary Slavic languages that productively uses the dual. The other two are Upper and Lower Sorbian. In this chapter, we will outline the present-day use of the dual in Slovenian, generally ignoring historical aspects, for which see, i.a., Tesnière (1925a), Belić (1934), Jakop (2008), Olander (2015). Also, the description will primarily be based on standard Slovenian as described/prescribed in Toporišič et al. (2001), mainly ignoring the great variation across different varieties of Slovenian (cf. Tesnière 1925a,b, Jakop 2008) in the actual forms of dual marking and the extent to which dual forms are distinct from the plural. The paradigms presented in the next section exist in entirety only in few dialects and in the prescribed standard variety. A small number of dialects of the South West, along the border between Italy and Slovenia, and the dialects of the South, along the border with Croatia, are without most of the dual forms and in some cases without the dual altogether, but for the most part, different dialects exhibit different amounts of dual forms. Central Slovenian dialects and dialects of the North and North-East use dual fully productively (cf. Jakop 2008 and Marušič et al. 2016 for a comprehensive map of the distribution of dual in Slovenian dialects).
Keywords: Slovenian, grammatical number, dual, meaning of dual
Published in RUNG: 13.08.2021; Views: 2568; Downloads: 0
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7.
Smart phones, smarter marketing: suggesting strategies through smart phones in India
Rajan Gupta, Saibal K. Pal, Saibal K. Pal, 2012, independent scientific component part or a chapter in a monograph

Abstract: Marketing via mobile phones, commonly known as Mobile (m)-Marketing, includes advertising, promotions, direct marketing and customer relationship management using mobile calls or mobile media like SMS and MMS. With over two billion mobile users currently available all over the world and a significant percentage switching to smart phones, marketers now have new opportunities to target users of such devices. This paper focuses on identifying and designing marketing strategies for different sectors and product/service categories in India using these smart devices and available services. Primary data collection has been carried out by interviewing marketing and store managers and also by collecting responses from users. We identify sectors like banking & financial services, education, health, real estate, airlines, tourism and hospitality and suggest interesting marketing opportunities for the mobile platform. We believe that these initiatives would open up new channels for customer engagement, branding, advertising and product promotion. We also feel that with regular addition of new players, the future holds bright for brands coming together, selling together and marketing together in the smartest possible way.
Keywords: marketing strategy, mobile marketing, smart phones, dual branding
Published in RUNG: 05.04.2021; Views: 2754; Downloads: 0
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8.
Do children derive exact meanings pragmatically? Evidence from a dual morphology language
Franc Marušič, Rok Žaucer, Amanda Saksida, Jessica Sullivan, Dimitrios Skordos, Longlong Wang, David Barner, 2021, original scientific article

Abstract: Number words allow us to describe exact quantities like sixty-three and (exactly) one. How do we derive exact interpretations? By some views, these words are lexically exact, and are therefore unlike other grammatical forms in language. Other theories, however, argue that numbers are not special and that their exact interpretation arises from pragmatic enrichment, rather than lexically. For example, the word one may gain its exact interpretation because the presence of the immediate successor two licenses the pragmatic inference that one implies “one, and not two”. To investigate the possible role of pragmatic enrichment in the development of exact representations, we looked outside the test case of number to grammatical morphological markers of quantity. In particular, we asked whether children can derive an exact interpretation of singular noun phrases (e.g., “a button”) when their language features an immediate “successor” that encodes sets of two. To do this, we used a series of tasks to compare English-speaking children who have only singular and plural morphology to Slovenian-speaking children who have singular and plural forms, but also dual morphology, that is used when describing sets of two. Replicating previous work, we found that English-speaking preschoolers failed to enrich their interpretation of the singular and did not treat it as exact. New to the present study, we found that 4- and 5-year-old Slovenian-speakers who comprehended the dual treated the singular form as exact, while younger Slovenian children who were still learning the dual did not, providing evidence that young children may derive exact meanings pragmatically.
Keywords: Acquisition of quantity expressions, Acquisition of exactness, Pragmatics of grammatical number, Inferences on quantity, Dual, Slovenian
Published in RUNG: 13.12.2020; Views: 3229; Downloads: 0
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9.
Countability, agreement and the loss of the dual in Russian
Arthur Stepanov, Penka Stateva, 2018, original scientific article

Keywords: agreement, atomicity, classifier, countability, dual number, numeral, Russian, Bulgarian
Published in RUNG: 21.03.2018; Views: 4665; Downloads: 0
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10.
Countability and the structure of numeral-based QPs
Arthur Stepanov, Penka Stateva, unpublished invited conference lecture

Keywords: countability, atomicity, numeral, agreement, dual number, classifier, russian, morphology, syntax, semantics
Published in RUNG: 07.02.2018; Views: 4686; Downloads: 0
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