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3. Diagnostics and Monitoring of COVID-19 Infection – Current UnderstandingMartina Bergant Marušič, Ario De Marco, 2020, review, book review, critique Keywords: SARS-CoV-2, RT-PCR, seroconversion, serum biomarkers, neutralizing antibodies
Published in RUNG: 30.09.2022; Views: 1826; Downloads: 22
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4. Identification of environmental stress conditions by comparative analysis of peroxidase activity in betulla pendula and pinus sp. : Group project reportPatrik Cingerli, Katarina Erker, Nina Žvab-Pernat, Darian Rampih, Miroslav Štrbac, Hena Zukić, Kenan Kapetanović, 2021, treatise, preliminary study, study Abstract: The study investigated the possibility of developing a biomarker to evaluate the stress level in trees. The analyses have been performed on tree samples appertaining to two different tree species and collected at two locations in Slovenia. The presence and the activity of the proteins – peroxidases was measured by the qualitative method of the agarose gel electrophoresis and the quantitative method of spectrometry. It was found out that by measuring the presence of the biomarkers and pigments in the tree samples we can determine the stress levels and thus the health status of trees.
Keywords: biomarkers, environmental stress, pigments, peroxidase
Published in RUNG: 29.09.2021; Views: 2943; Downloads: 0
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6. Exhaled breath metabolomics reveals a pathogen-specific response in a rat pneumonia model for two human pathogenic bacteria: a proof-of-concept studyPouline M van Oort, Iain R. White, 2019, original scientific article Abstract: Volatile organic compounds in breath can reflect host and pathogen metabolism and might be used to diagnose pneumonia. We hypothesized that rats with Streptococcus pneumoniae (SP) or Pseudomonas aeruginosa (PA) pneumonia can be discriminated from uninfected controls by thermal desorption-gas chromatography-mass-spectrometry (TD-GC-MS) and selected ion flow tube-mass spectrometry (SIFT-MS) of exhaled breath. Male adult rats (n = 50) received an intratracheal inoculation of 1) 200 µl saline, or 2) 1 × 107 colony-forming units of SP or 3) 1 × 107 CFU of PA. Twenty-four hours later the rats were anaesthetized, tracheotomized, and mechanically ventilated. Exhaled breath was analyzed via TD-GC-MS and SIFT-MS. Area under the receiver operating characteristic curves (AUROCCs) and correct classification rate (CCRs) were calculated after leave-one-out cross-validation of sparse partial least squares-discriminant analysis. Analysis of GC-MS data showed an AUROCC (95% confidence interval) of 0.85 (0.73-0.96) and CCR of 94.6% for infected versus noninfected animals, AUROCC of 0.98 (0.94-1) and CCR of 99.9% for SP versus PA, 0.92 (0.83-1.00), CCR of 98.1% for SP versus controls and 0.97 (0.92-1.00), and CCR of 99.9% for PA versus controls. For these comparisons the SIFT-MS data showed AUROCCs of 0.54, 0.89, 0.63, and 0.79, respectively. Exhaled breath analysis discriminated between respiratory infection and no infection but with even better accuracy between specific pathogens. Future clinical studies should not only focus on the presence of respiratory infection but also on the discrimination between specific pathogens.
Keywords: biomarkers, exhaled breath analysis, infection, pneumonia
Published in RUNG: 22.07.2019; Views: 3813; Downloads: 0
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8. Urinary Extracellular Vesicle Biomarkers in Urological Cancers: From Discovery Towards Clinical ImplementationBert Dhondt, Jan Van Deun, Silke Vermaerke, Ario De Marco, Nicolaas Lumen, Olivier De Wever, An Hendrix, 2018, review article Keywords: Extracellular vesicles, cancer biomarkers, diagnostics
Published in RUNG: 04.05.2018; Views: 4638; Downloads: 0
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9. Identification of stress biomarkers for drought and increased soil temperature in seedlings of European beech (Fagus sylvatica L.)Milica Popovič, Marco Gregori, Dominik Vodnik, Mitja Ferlan, Tanja Mrak, Ines Straus, Natahan McDowell, Hojka Kraigher, Ario De Marco, 2017, original scientific article Keywords: Drought biomarkers, peroxidases, scavanging activity
Published in RUNG: 23.10.2017; Views: 4586; Downloads: 0
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