1. Biological applications of porous polymers and covalent organic frameworksTina Škorjanc, 2023, invited lecture at foreign university Abstract: Porous organic polymers (POPs) and covalent organic frameworks (COFs) have gained significant attention in the scientific community for a wide array of applications because of their attractive physical and chemical properties. Porosity of these materials provides ample surface area for interaction with targets, while crystallinity allows for highly specific structural tuning. In this seminar, I will present two strategies of utilizing these features of newly prepared materials in biosensing. Firstly, a cationic POP was synthesized, deposited onto interdigitated electrode arrays via a nontraditional electrophoresis technique, and utilized for electrochemical sensing of bacterial cells. As the principle of detection relied on electrostatic interactions between the cationic POP and the anionic bacterial surface, the sensor operated for both Gram-positive and Gram-negative bacteria. Secondly, a small-molecule nitroimidazole target for hypoxia, a low oxygen environment present in tumors, was post-synthetically conjugated to the pores of a fluorescent COF. This material served as a useful hypoxia imaging agent in cancerous cells. The seminar will conclude with some future perspectives on POPs and COFs in biological applications followed by Q & A.
Keywords: Porous organic polymers, covalent organic frameworks, biosensors, hypoxia
Published in RUNG: 13.07.2023; Views: 453; Downloads: 0
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3. Native llama nanobody library panning performed by phage and yeast display provides binders suitable for C-reactive protein detectionSandra Oloketuyi, Robert Alvin Bernedo-Navarro, Andreas Christmann, Justyna Borkowska, Giulia Cazzaniga, Horst Wilhelm Schuchmann, Joanna Niedziółka-Jönsson, Katarzyna Szot-Karpińska, Harald Kolmar, Ario De Marco, 2021, original scientific article Keywords: phage display, yeast display, nanobodies, electrochemical impedance biosensors
Published in RUNG: 06.12.2021; Views: 1223; Downloads: 37
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4. Electrochemical immunosensor functionalized with nanobodies for the detection of the toxic microalgae Alexandrium minutum using glassy carbon electrode modified with gold nanoparticlesSandra Oloketuyi, Elisa Mazzega, Janez Zavašnik, Kingkan Pungjunun, Kurt Kalcher, Ario De Marco, Eda Mehmeti, 2020, original scientific article Keywords: biosensors, toxic microalgae, nanobodies, impedance
Published in RUNG: 07.02.2020; Views: 2867; Downloads: 0
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5. Functionalized nanobodies: A bio-recognition molecule for the detection of the toxic microalgae Alexandrium minutum by means of an electrochemical immunosensorSandra Oloketuyi, Elisa Mazzega, Eda Mehmeti, Kurt Kalcher, Ario de Marco, 2019, published scientific conference contribution abstract Keywords: Biosensors, nanobodies, impedance, immunocapture, SpyTag
Published in RUNG: 18.11.2019; Views: 3639; Downloads: 101
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6. Quantification of Circulating Cancer Biomarkers via Sensitive Topographic Measurements on Single Binder NanoarraysElena Ambrosetti, Pamela Paoletti, Alessandro Bosco, Pietro Parisse, Denis Scaini, Elda Tagliabue, Ario de Marco, Loredana Casalis, 2017, original scientific article Keywords: Biosensors, immuno-capture, nanobodies, HER2, cancer diagostics
Published in RUNG: 22.06.2017; Views: 3721; Downloads: 210
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7. Optimised calibration procedure for bioanalytical determination of organophosphate pesticides in apple juices by immobilised AChEBoris Pihlar, Klavdija Mežnar, Mladen Franko, Lea Pogačnik, 2003, original scientific article Abstract: Optimised calibration procedure for bioanalytical determination of organophosphate pesticides in apple juices by immobilised AChE
Keywords: analitske metode, biosenzorji, pesticidi, sadni sokovi, analytical techniques, biosensors, FIA, flow injection analysis, pesticides, fruit juices
Published in RUNG: 17.05.2016; Views: 4445; Downloads: 16
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