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1.
A New Variant of Dynamic Pickup and Delivery Problem with Time Windows
Petr Valenta, Hana Rudová, Soumen Atta, 2020, published scientific conference contribution

Abstract: Motivated by the challenges faced by a logistics company, we present a new variant of the dynamic capacitated pickup and delivery problem with time windows (PDPTW) where excessive changes of unaffected routes are undesirable. In real-life scenarios, different dynamism sources such as canceled requests, change of demands, change of pickup, or delivery time windows often disrupt the existing planning of routes. The static PDPTW is solved with the current information about the problem well before executing the routes, such as the previous night. We present an algorithmic idea of a dynamic solver quickly addressing changes that occur due to the dynamism while avoiding excessive modifications to the previous solution. Since the company has not yet the dynamic data, new dynamic instances are generated from the existing static PDPTW instances in the literature. Preliminary results demonstrate that we can quickly incorporate the required changes. Future perspectives of this ongoing work are discussed in the end.
Keywords: Dynamic Pickup and Delivery Problem, Time Windows, Heuristic
Published in RUNG: 17.04.2023; Views: 1016; Downloads: 0
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Good reasons for targeting SARS-CoV-2 by engineered extracellular vesicles
Ario De Marco, Lucio Barile, 2022, short scientific article

Keywords: Extracellular vesicles, SARS-CoV-2, targeted delivery
Published in RUNG: 12.04.2022; Views: 1298; Downloads: 0
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Covalent Calix[4]arene Nanocapsules for Efficient Camptothecin Delivery
Dinesh Shetty, Tina Skorjanc, Ali Trabolsi, 2019, published scientific conference contribution abstract

Keywords: drug delivery, calixarene, nanocapsule, self-assembly, camptothecin, breast cancer
Published in RUNG: 10.09.2020; Views: 2467; Downloads: 0
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Covalent organic frameworks for biomedical and environmental applications
Tina Skorjanc, invited lecture at foreign university

Keywords: pollutant removal, covalent organic polymers, drug delivery, imaging
Published in RUNG: 03.09.2020; Views: 2419; Downloads: 0
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Maternal and fetal hair cortisol concentrations in beef cattle at delivery
Tanja Peric, Monica Probo, Antonella Comin, Maria Cristina Veronesi, Marta Montillo, Alberto Prandi, 2018, published scientific conference contribution abstract

Abstract: Hypothalamus-pituitary-adrenal (HPA) axis of both mother and fetus, is one of key mechanisms involved in fetal programming. Cortisol, the end-product of this axis, plays a critical role in regulating fetal and new-born metabolism and development. The aim of the study was to evaluate maternal and fetal cortisol concentrations shortly after delivery on hair samples non-invasively collected. The study was carried out on 11 pairs of beef cows and their calves (calves were 12 because of one case of twins) from the same farm and subjected to the same managerial conditions. Hair from new-born calves and from their mothers was collected on the day of birth shaving their withers to the level of the skin. The hair cortisol concentrations (HCC) were determined by RIA as previously described (Peric et al. 2013: J Dairy Sci 96:3023–3027). The results showed that fetal and maternal HCC ranged from 16.11 to 40.43 pg/mg and from 1.88 to 15.73 pg/mg respectively, with fetal and maternal mean ± SE HCC of 23.72 ± 2.21 and 6.40 ± 1.32 pg/mg respectively (p < 0.001). Fetal HCC were on average 3.5 higher than those of mothers but this ratio differed among the pairs. These differences were also found among the twin calves. These results indicate that in beef cows-and-calves pairs, although HCC at delivery were always higher in calves than in cows, the ratio between fetal and maternal HCC differs among pairs, suggesting an individuality in the fetal programming processes that may also rely on genetic and epigenetic factors.
Keywords: hair, cortisol, cattle, delivery
Published in RUNG: 09.04.2019; Views: 3316; Downloads: 0
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