101. Outlier based literature exploration for cross-domain linking of Alzheimer's disease and gut microbiotaDonatella Gubiani, Elsa Fabbretti, Bojan Cestnik, Nada Lavrač, Tanja Urbančič, 2017, original scientific article Abstract: In knowledge discovery, experts frequently need to combine knowledge from different domains to get new insights and derive new conclusions. Intelligent systems should support the experts in the search for relationships between concepts from different domains, where huge amounts of possible combinations require the systems to be efficient but also sufficiently general, open and interactive to enable the experts to creatively guide the discovery process. The paper proposes a cross-domain literature mining methodology that achieves this functionality by combining the functionality of two complementary text mining tools: clustering and topic ontology creation tool OntoGen and cross-domain bridging terms exploration tool CrossBee. Focusing on outlier documents identified by OntoGen contributes to the efficiency, while CrossBee allows for flexible and user-friendly bridging concepts exploration and identification. The proposed approach, which is domain independent and can support cross-domain knowledge discovery in any field of science, is illustrated on a biomedical case study dealing with Alzheimer’s dis- ease, one of the most threatening age-related diseases, deteriorating lives of numerous individuals and challenging the ageing society as a whole. By applying the proposed methodology to Alzheimer’s disease and gut microbiota PubMed articles, we have identified Nitric oxide synthase (NOS) as a potentially valuable link between these two domains. The results support the hypothesis of neuroinflammatory nature of Alzheimer’s disease, and is indicative for the quest for identifying strategies to control nitric oxide- associated pathways in the periphery and in the brain. By addressing common mediators of inflammation using literature-based discovery, we have succeeded to uncover previously unidentified molecular links between Alzheimer’s disease and gut microbiota with a multi-target therapeutic potential.
Keywords: Literature-based discovery, Outlier detection, Alzheimer's disease, Gut microbiome
Published in RUNG: 26.05.2017; Views: 5004; Downloads: 0
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102. Biofunctionalized AlGaN/GaN high electron mobility transistor for DNA hybridization detectionResham Thapa, Siddharth Alur, Kyusang Kim, Fei Tong, Yogesh Sharma, Moonil Kim, Claude Ahyi, Jing Dai, Jong Wook Hong, Michael Bozack, John Williams, Ahjeong Son, Amir Dabiran, Minseo Park, 2012, original scientific article Keywords: AlGaN/GaN HEMT, DNA hybridization detection
Published in RUNG: 16.01.2017; Views: 4725; Downloads: 0
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103. SiPM and front-end electronics development for Cherenkov light detectionG. Ambrosi, Andrej Filipčič, Gašper Kukec Mezek, Samo Stanič, Serguei Vorobiov, Lili Yang, Gabrijela Zaharijas, Danilo Zavrtanik, Marko Zavrtanik, 2015, published scientific conference contribution Keywords: Cherenkov Telescope Array (CTA), Cherenkov light detection R&D, SiPM camera for CTA, front-end electronics
Published in RUNG: 16.01.2017; Views: 3806; Downloads: 209
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104. Determination of Trace Cr(VI) with Diphenylcarbazide by μFIA–Thermal Lens MicroscopyTatyana Gor’kova, Michail Proskurnina, Mingqiang Liu, Mladen Franko, 2016, original scientific article Abstract: The optimum reaction parameters for the interaction of hexavalent chromium [Cr(VI)] with diphenylcarbazide in microfluidic
chips (μFIA) with thermal-lens microscopic detection were selected. The characteristic feature of the applied
flow scheme is the injection of the reagent into the stream containing the test metal, which enables in-field and
real-time monitoring of Cr(VI) simply by flowing the sample continuously through the microchip. The limit of detection
of Cr(VI) under the selected conditions (signal generating wavelength, 514.5 nm; excitation power, 100 mW; detection
position, 10 cm downstream from the mixing zone of the microchip; flow rate 10 μL min–1; injection volume,
1.4 μL) is 15 ng mL–1 (2.9 × 10–7 mol L–1). The linear range is 40 ng mL–1 – 10 μg mL–1 with a relative standard deviation
no higher than 10% in the concentration range 0.1–1 μg mL–1. The online monitoring by this scheme provides the
possibility of up to 360 analyses per hour.
Keywords: Photothermal lensing, thermal-lens microscopic detection, microfluidic applications, μFIA, hexavalent
chromium, diphenylcarbazide
Published in RUNG: 12.12.2016; Views: 4502; Downloads: 0
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105. High Energy AstrophysicsLili Yang, unpublished conference contribution Abstract: I was invited as a lecturer at the Sumer School on Astrophysics and Astroparticles in Petnica Serbia. I gave talks on "High Energy Astrophysics", where I mainly focused on the production, propagation and detection of high energy astroparticles. Especially, I introduced the current experiments and technique and facilities.
Keywords: High-energy astroparticles, experiments, detection, production
Published in RUNG: 06.12.2016; Views: 5553; Downloads: 0
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106. TARGET: toward a solution for the readout electronics of the Cherenkov Telescope ArrayL. Tibaldo, Andrej Filipčič, Gašper Kukec Mezek, Samo Stanič, Serguei Vorobiov, Lili Yang, Gabrijela Zaharijas, Danilo Zavrtanik, Marko Zavrtanik, 2015, published scientific conference contribution Keywords: very-high energy (VHE) gamma-ray astronomy, air Cherenkov imaging detection technique, Cherenkov Telescope Array (CTA), TARGET readout electronics for CTA cameras
Published in RUNG: 18.11.2016; Views: 5053; Downloads: 219
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107. The Auger Engineering Radio Array and multi-hybrid cosmic ray detectionE. M. Holt, Andrej Filipčič, Gašper Kukec Mezek, Ahmed Saleh, Samo Stanič, Marta Trini, Darko Veberič, Serguei Vorobiov, Lili Yang, Danilo Zavrtanik, Marko Zavrtanik, 2016, published scientific conference contribution Keywords: cosmic rays (CR), extensive air showers, EAS radio emission, Pierre Auger Observatory, Auger Engineering Radio Array, multi-hybrid CR detection
Published in RUNG: 09.11.2016; Views: 4398; Downloads: 266
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