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1.
Antibiotics and their different application strategies in controlling the biofilm forming pathogenic bacteria
Fazlurrahman Khan, Dung T N Pham, Sandra Oloketuyi, Young-Mog Kim, 2020, review article

Abstract: Background: The establishment of a biofilm by most pathogenic bacteria has been known as one of the resistance mechanisms against antibiotics. A biofilm is a structural component where the bacterial community adheres to the biotic or abiotic surfaces by the help of Extracellular Polymeric Substances (EPS) produced by bacterial cells. The biofilm matrix possesses the ability to resist several adverse environmental factors, including the effect of antibiotics. Therefore, the resistance of bacterial biofilm-forming cells could be increased up to 1000 times than the planktonic cells, hence requiring a significantly high concentration of antibiotics for treatment. Methods: Up to the present, several methodologies employing antibiotics as an anti-biofilm, antivirulence or quorum quenching agent have been developed for biofilm inhibition and eradication of a pre-formed mature biofilm. Results: Among the anti-biofilm strategies being tested, the sub-minimal inhibitory concentration of several antibiotics either alone or in combination has been shown to inhibit biofilm formation and down-regulate the production of virulence factors. The combinatorial strategies include (1) combination of multiple antibiotics, (2) combination of antibiotics with non-antibiotic agents and (3) loading of antibiotics onto a carrier. Conclusion: The present review paper describes the role of several antibiotics as biofilm inhibitors and also the alternative strategies adopted for applications in eradicating and inhibiting the formation of biofilm by pathogenic bacteria.
Found in: ključnih besedah
Summary of found: ...quenching agent have been developed for biofilm inhibition and eradication of a pre-formed mature biofilm. Results:...
Keywords: Antibiotics, biofilm inhibition, multiple antibiotics, pathogenic bacteria, resistance mechanism, virulence factors
Published: 14.01.2021; Views: 732; Downloads: 0
.pdf Fulltext (2,61 MB)

2.
Diversity of bacteria and bacterial products as antibiofilm and antiquorum sensing drugs against pathogenic bacteria
Fazlurrahman Khan, Sandra Oloketuyi, Young-Mog Kim, 2019, review article

Abstract: The increase in antibiotic resistance of pathogenic bacteria has led to the development of new therapeutic approaches to inhibit biofilm formation as well as interfere quorum sensing (QS) signaling systems. The QS system is a phenomenon in which pathogenic bacteria produce signaling molecules that are involved in cell to cell communication, production of virulence factors, biofilm maturation, and several other functions. In the natural environment, several non-pathogenic bacteria are present as mixed population along with pathogenic bacteria and they control the behavior of microbial community by producing secondary metabolites. Similarly, non-pathogenic bacteria also take advantages of the QS signaling molecule as a sole carbon source for their growth through catabolism with enzymes. Several enzymes are produced by bacteria which disrupt the biofilm architecture by degrading the composition of extracellular polymeric substances (EPS) such as exopolysaccharide, extracellular- DNA and protein. Thus, the interference of QS system by bacterial metabolic products and enzymatic catalysis, modification of the QS signaling molecules as well as enzymatic disruption of biofilm architecture have been considered as the alternative therapeutic approaches. This review article elaborates on the diversity of different bacterial species with respect to their metabolic products as well as enzymes and their molecular modes of action. The bacterial enzymes and metabolic products will open new and promising perspectives for the development of strategies against the pathogenic bacterial infections.
Found in: ključnih besedah
Summary of found: ...Bacteria, biofilm, quorum sensing, inhibition, metabolites, pathogen, virulence....
Keywords: Bacteria, biofilm, quorum sensing, inhibition, metabolites, pathogen, virulence.
Published: 18.01.2021; Views: 749; Downloads: 0
.pdf Fulltext (2,17 MB)

3.
Inhibition strategies of Listeria monocytogenes biofilms- Current knowledge and future outlooks.
Sandra Oloketuyi, Fazlurrahman Khanna, 2017, review article

Abstract: There is an increasing trend in the food industry on the Listeria monocytogenes biofilm formation and inhibition. This is attributed to its easy survival on contact surfaces, resistance to disinfectants or antibiotics and growth under the stringent condition used for food processing and preservation thereby leading to food contamination products by direct or indirect exposure. Though, there is a lack of conclusive evidences about the mechanism of biofilm formation, in this review, the concept of biofilm formation and various chemical, physical, and green technology approaches to prevent or control the biofilm formed is discussed. State-of-the-art approaches ranging from the application of natural to synthetic molecules with high effectiveness and non-toxicity targeted at the different steps of biofilm formation could positively influence the biofilm inhibition in the future.
Found in: ključnih besedah
Keywords: Listeria monocytogenes, biofilm, food industry, inhibition, pathogen
Published: 14.01.2021; Views: 718; Downloads: 0
.pdf Fulltext (697,40 KB)
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4.
Antibacterial activity of seed extracts of Okra (Abelmoschus esculentus) against selected pathogen
Sandra Oloketuyi, 2017, original scientific article

Abstract: The aim of the study was to determine the antibacterial potency of aqueous and ethanoic extracts of Abelmoschus esculentus seeds. Antibacterial activity of aqueous and ethanoic extracts of A. esculentus seeds were evaluated against selected foodborne pathogens; Listeria monocytogenes, Bacillus cereus, Salmonella enterica, Staphylococcus aureus and Escherichia coli) using agar well diffusion method by measuring the clear zone of inhibition diameter in (mm). It was observed that the aqueous and ethanoic extracts of the four samples of A. esculentus seeds showed broad range of inhibitory activity against the test bacteria especially L. monocytogenes. Thus, A. esculentus seed has a great potential as effective antilisterial and antibacterial activity. Practical Application: Consumption of okra seeds is highly recommended for its nutritive value and antibacterial activity against pathogens, which are most commonly attributed to foodborne diseases such as listeriosis, diarrhea, and salmonellosis. Also, further study could be conducted by isolating and identifying the active ingredient responsible for antibacterial potency for pharmaceutical purpose.
Found in: ključnih besedah
Summary of found: ...method by measuring the clear zone of inhibition diameter in (mm). It was observed that...
Keywords: Abelmoschus esculentus, antibacterial activity, foodborne pathogens, extracts, inhibition
Published: 14.01.2021; Views: 590; Downloads: 0
.pdf Fulltext (547,28 KB)

5.
Chitosan and their derivatives: Antibiofilm drugs against pathogenic bacteria
Fazlurrahman Khan, Dong Pham, Sandra Oloketuyi, Panchanathan Manivasagan, Junghwan Oh, Young-Mog Kim, 2020, review article

Abstract: Biofilm formed by several pathogenic bacteria results in the development of resistance against antimicrobial compounds. The polymeric materials present in the biofilm architecture hinder the entry of antimicrobial compounds through the surface of bacterial cells which are embedded as well as enclosed beneath the biofilm matrix. Recent and past studies explored the alternative approaches to inhibit the formation of biofilm by different agents isolated from plants, animals, and microbes. Among these agents, chitosan and its derivatives have got more attention due to their properties such as biodegradability, biocompatibility, non-allergenic and non-toxicity. Recent researches have focused on employing chitosan and its derivatives as effective agents to inhibit biofilm formation and attenuate virulence properties by various pathogenic bacteria. Such antibiofilm activity of chitosan and its derivatives can be further enhanced by conjugation with a wide range of bioactive compounds. The present review describes the antibiofilm properties of chitosan and its derivatives against the pathogenic bacteria. This review also summarizes the mechanisms of biofilm inhibition exhibited by these molecules. The knowledge of the antibiofilm activities of chitosan and its derivatives as well as their underlying mechanisms provides essential insights for widening their applications in the future.
Found in: ključnih besedah
Summary of found: ...review also summarizes the mechanisms of biofilm inhibition exhibited by these molecules. The knowledge of...
Keywords: Antibiofilm, Biofilm inhibition, Chitosan, Chitosan derivatives, Pathogenic bacteria
Published: 14.01.2021; Views: 757; Downloads: 0
.pdf Fulltext (3,95 MB)

6.
Molecules involved in motility regulation in Escherichia coli cells: a review
Fazlurrahman Khan, Nazia Tabassum, Dung :Pham, Sandra Oloketuyi, Young-Mog Kim, 2020, original scientific article

Abstract: The initial colonization of the host organism by commensal, probiotic, and pathogenic Escherichia coli strains is an important step in the development of infections and biofilms. Sensing and colonization of host cell surfaces are governed by flagellar and fimbriae/pili appendages, respectively. Biofilm formation confers great advantages on pathogenic E. coli cells such as protection against the host immune system, antimicrobial agents, and several environmental stress factors. The transition from planktonic to sessile physiological states involves several signaling cascades and factors responsible for the regulation of flagellar motility in E. coli cells. These regulatory factors have thus become important targets to control pathogenicity. Hence, attenuation of flagellar motility is considered a potential therapy against pathogenic E. coli. The present review describes signaling pathways and proteins involved in direct or indirect regulation of flagellar motility. Furthermore, application strategies for antimotility natural or synthetic compounds are discussed also.
Found in: ključnih besedah
Summary of found: ...Biofilm formation, Escherichia coli, inhibition, motility, pathogenesis...
Keywords: Biofilm formation, Escherichia coli, inhibition, motility, pathogenesis
Published: 14.01.2021; Views: 955; Downloads: 0
.pdf Fulltext (2,42 MB)

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