1. Foods2012 Keywords: food sciences and technology, food chemistry and physical properties, food engineering and production, food security and safety, food toxicology, sensory and food quality, food analysis, functional foods, food and health, food psychology, food and environment
Published in RUNG: 10.05.2024; Views: 1644; Downloads: 4
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2. The influence of selected indigenous yeasts on Pinot Noir wine colour propertiesJelena Topić, Lorena Butinar, Guillaume Antalick, Melita Sternad Lemut, Mitja Martelanc, Alen Albreht, Dorota Korte, Branka Mozetič Vodopivec, 2021, original scientific article Keywords: Pinot Noir, wine colour, yeasts, non-Saccharomyces, sensory
Published in RUNG: 07.07.2021; Views: 3611; Downloads: 0
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3. Volatile and sensory profiling of Shiraz wine in response to alcohol management: comparison of harvest timing versus technological approachesRocco Longo, John W. Blackman, Guillaume Antalick, Peter J. Torley, Suzy Y. Rogers, Leigh Schmidtke, 2018, original scientific article Keywords: Common Component Specific Weights Analysis, polypropylene membrane, sensory descriptive analysis, sequential harvest, volatiles, wine alcohol-reduction
Published in RUNG: 17.09.2018; Views: 4774; Downloads: 0
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4. A comparative study of partial dealcoholisation versus early harvest: Effects on wine volatile and sensory profilesRocco Longo, John.W Blackman, Guillaume Antalick, Peter J. Torley, Suzy.Y Rogers, Leigh Schmidtke, 2018, original scientific article Keywords: Common component and specific weights analysis, Dealcoholisation, Early harvest, Evaporative perstraction, Lower alcohol wine, Reverse osmosis, Sensory descriptive analysis, Wine
Published in RUNG: 17.09.2018; Views: 4799; Downloads: 0
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6. Harvesting and blending options for lower alcohol wines: a sensory and chemical investigationRocco Longo, John W. Blackman, Guillaume Antalick, Peter J. Torley, Suzy Y. Rogiers, Leigh Schmidtke, 2017, original scientific article Keywords: PLS regression, early harvest, herbaceous, reduced-alcohol, sensory descriptive analysis, volatiles
Published in RUNG: 30.08.2017; Views: 5384; Downloads: 0
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9. The scaffold protein calcium/calmodulin-dependent serine protein kinase controls ATP release in sensory ganglia upon P2X3 receptor activation and is part of an ATP keeper complex.Tanja Bele, Elsa Fabbretti, 2016, original scientific article Abstract: P2X3 receptors, gated by extracellular ATP, are expressed by sensory neurons and are involved in peripheral nociception and pain sensitization. The ability of P2X3 receptors to transduce extracellular stimuli into neuronal signals critically depends on the dynamic molecular partnership with the calcium/calmodulin-dependent serine protein kinase (CASK). The present work used trigeminal sensory neurons to study the impact that activation of P2X3 receptors (evoked by the agonist α,β-meATP) has on the release of endogenous ATP and how CASK modulates this phenomenon. P2X3 receptor function was followed by ATP efflux via Pannexin1 (Panx1) hemichannels, a mechanism that was blocked by the P2X3 receptor antagonist A-317491, and by P2X3 silencing. ATP efflux was enhanced by nerve growth factor, a treatment known to potentiate P2X3 receptor function. Basal ATP efflux was not controlled by CASK, and carbenoxolone or Pannexin silencing reduced ATP release upon P2X3 receptor function. CASK-controlled ATP efflux followed P2X3 receptor activity, but not depolarization-evoked ATP release. Molecular biology experiments showed that CASK was essential for the transactivation of Panx1 upon P2X3 receptor activation. These data suggest that P2X3 receptor function controls a new type of feed-forward purinergic signaling on surrounding cells, with consequences at peripheral and spinal cord level. Thus, P2X3 receptor-mediated ATP efflux may be considered for the future development of pharmacological strategies aimed at containing neuronal sensitization. P2X3 receptors are involved in sensory transduction and associate to CASK. We have studied in primary sensory neurons the molecular mechanisms downstream P2X3 receptor activation, namely ATP release and partnership with CASK or Panx1. Our data suggest that CASK and P2X3 receptors are part of an ATP keeper complex, with important feed-forward consequences at peripheral and central level.
Keywords: DRG, hemichannels, pain, purinergic signaling, sensory neurons
Published in RUNG: 19.01.2017; Views: 5578; Downloads: 0
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