Repozitorij Univerze v Novi Gorici

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Naslov:Nanobodies against surface biomarkers enable the analysis of tumor genetic heterogeneity in uveal melanoma Patient Derived Xenografts
Avtorji:ID Crepin, Ronan, Institut Curie (Avtor)
ID Gentien, David, Institut Curie (Avtor)
ID Duche, Angeline, Institut Curie (Avtor)
ID Rapinat, Audrey, Institut Curie (Avtor)
ID Reyes, Cecile, Institut Curie (Avtor)
ID Nemati, Fariba, Institut Curie (Avtor)
ID Massonnet, Gerald, Institut Curie (Avtor)
ID Deacaudin, Didier, Institut Curie (Avtor)
ID Djander, Selma, Institut Curie (Avtor)
ID Moutel, Sandrine, Institut Curie (Avtor)
ID Desrumeaux, Klervi Even, Institut Curie (Avtor)
ID Cassoux, Nathalie, Institut Curie (Avtor)
ID Piperno-Neumann, Sophie, Institut Curie (Avtor)
ID Amigorena, Sebastian, Institut Curie (Avtor)
ID Perez, Franck, Institut Curie (Avtor)
ID Roman-Roman, Sergio, Institut Curie (Avtor)
ID De Marco, Ario, UNG (Avtor)
Datoteke: Gradivo nima datotek, ki so prostodostopne za javnost. Gradivo je morda fizično dosegljivo v knjižnici fakultete, zalogo lahko preverite v COBISS-u. Povezava se odpre v novem oknu
Jezik:Angleški jezik
Vrsta gradiva:Delo ni kategorizirano
Tipologija:1.01 - Izvirni znanstveni članek
Organizacija:UNG - Univerza v Novi Gorici
Opis:Monoclonal antibodies specific for biomarkers expressed on the surface of uveal melanoma (UM) cells would simplify the immune-capture and genomic characterization of heterogeneous tumor cells originated from patient derived xenografts (PDXs). Antibodies against four independent tumor antigens were isolated by panning a nanobody synthetic library. Such antibodies enabled flow-cytometry-based sorting of distinct cell sub-populations from UM PDXs and to analyze their genomic features. The complexity and specificity of the biochemical and genomic biomarker combinations mirrored the UM tumor polyclonality. The data showed that MUC18 is highly and universally displayed at the surface of UM cells with different genetic background and consequently represents a reliable pan-biomarker for their identification and purification. In contrast, the other three biomarkers were detected in very variable combinations in UM PDX cells. The availability of the identified nanobodies will be instrumental in developing clone-specific drug evaluation and rational clinical strategies based on accurate genomic profiling
Ključne besede:nanobodies, uveal melanoma, patient derived xenografts, MUC18, membrane surface biomarkers, panning, tumor polyclonality
Verzija publikacije:Objavljena publikacija
Leto izida:2017
Št. strani:11
Številčenje:30
PID:20.500.12556/RUNG-3064-55912669-33a0-6520-c8d7-18453b1b60b4 Novo okno
COBISS.SI-ID:4768763 Novo okno
DOI:10.1111/pcmr.12577 Novo okno
NUK URN:URN:SI:UNG:REP:TFTBEVVZ
Datum objave v RUNG:19.04.2017
Število ogledov:5658
Število prenosov:0
Metapodatki:XML RDF-CHPDL DC-XML DC-RDF
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Skupna ocena:(0 glasov)
Vaša ocena:Ocenjevanje je dovoljeno samo prijavljenim uporabnikom.
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Gradivo je del revije

Naslov:Pigment Cell and Melanoma Research
Založnik:Wiley: 12 months
Leto izida:2017
ISSN:1755-1471

Licence

Licenca:CC BY-NC-ND 4.0, Creative Commons Priznanje avtorstva-Nekomercialno-Brez predelav 4.0 Mednarodna
Povezava:http://creativecommons.org/licenses/by-nc-nd/4.0/deed.sl
Opis:Najbolj omejujoča licenca Creative Commons. Uporabniki lahko prenesejo in delijo delo v nekomercialne namene in ga ne smejo uporabiti za nobene druge namene.
Začetek licenciranja:19.04.2017

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