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Title:Real-time multi-marker measurement of organic compounds in human breath: Towards fingerprinting breath
Authors:ID White, Iain R., Department of Chemistry, University of Leicester, Leicester, LE1 7RH, United Kingdom (Author)
ID Willis, Kerry A, Department of Chemistry, University of Leicester, Leicester, LE1 7RH, United Kingdom (Author)
ID Whyte, Christopher, Department of Chemistry, University of Leicester, Leicester, LE1 7RH, United Kingdom (Author)
ID Cordell, Rebecca, Department of Chemistry, University of Leicester, Leicester, LE1 7RH, United Kingdom (Author)
ID Blake, Robert S, Department of Chemistry, University of Leicester, Leicester, LE1 7RH, United Kingdom (Author)
ID Wardlaw, Andrew J, Department of Infection, Immunity and Inflammation, University of Leicester, Glenfield Hospital, Leicester, United Kingdom (Author)
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Language:English
Work type:Not categorized
Typology:1.01 - Original Scientific Article
Organization:UNG - University of Nova Gorica
Abstract:The prospects for exploiting proton transfer reaction-time of flight-mass spectrometry (PTR-ToF-MS) in medical diagnostics are illustrated through a series of case studies. Measurements of acetone levels in the breath of 68 healthy people are presented along with a longitudinal study of a single person over a period of 1 month. The median acetone concentration across the population was 484 ppbV with a geometric standard deviation (GSD) of 1.6, whilst the average GSD during the single subject longtitudinal study was 1.5. An additional case study is presented which highlights the potential of PTR-ToF-MS in pharmacokinetic studies, based upon the analysis of online breath samples of a person following the consumption of ethanol. PTR-ToF-MS comes into its own when information across a wide mass range is required, particularly when such information must be gathered in a short time during a breathing cycle. To illustrate this property, multicomponent breath analysis in a small study of cystic fibrosis patients is detailed, which provides tentative evidence that online PTR-ToF-MS analysis of tidal breath can distinguish between active infection and non-infected patients.
Keywords:Volatile Organic Compounds, breath, proton transfer reaction mass spectrometry, Cystic Fibrosis
Year of publishing:2013
Number of pages:11
Numbering:1, 7
PID:20.500.12556/RUNG-4640-dd4a6260-2c1b-36ca-78ff-f9a96c3be1ca New window
COBISS.SI-ID:5423867 New window
DOI:10.1088/1752-7155/7/1/017112 New window
NUK URN:URN:SI:UNG:REP:WRX9CNKR
Publication date in RUNG:22.07.2019
Views:3627
Downloads:0
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