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Title:A long-term study on female mice fed on a genetically modified soybean: effects on liver ageing.
Authors:ID Malatesta, Manuela, Università di Verona (Author)
ID Boraldi, Federica, Università di Modena e Reggio Emilia (Author)
ID Annovi, Giulia, Università di Modena e Reggio Emilia (Author)
ID Baldelli, Beatrice, Università di Urbino (Author)
ID Battistelli, Serafina, Università di Urbino (Author)
ID Baggiogera, Marco, Università di Pavia (Author)
ID Quaglino, Daniela, Università di Modena e Reggio Emilia (Author)
Files: This document has no files that are freely available to the public. This document may have a physical copy in the library of the organization, check the status via COBISS. Link is opened in a new window
Language:English
Work type:Not categorized
Typology:1.01 - Original Scientific Article
Organization:UNG - University of Nova Gorica
Abstract:Liver represents a suitable model for monitoring the effects of a diet, due to its key role in controlling the whole metabolism. Although no direct evidence has been reported so far that genetically modified (GM) food may affect health, previous studies on hepatocytes from young female mice fed on GM soybean demonstrated nuclear modifications involving transcription and splicing pathways. In this study, the effects of this diet were studied on liver of old female mice in order to elucidate possible interference with ageing. The morpho-functional characteristics of the liver of 24-month-old mice, fed from weaning on control or GM soybean, were investigated by combining a proteomic approach with ultrastructural, morphometrical and immunoelectron microscopical analyses. Several proteins belonging to hepatocyte metabolism, stress response, calcium signalling and mitochondria were differentially expressed in GM-fed mice, indicating a more marked expression of senescence markers in comparison to controls. Moreover, hepatocytes of GM-fed mice showed mitochondrial and nuclear modifications indicative of reduced metabolic rate. This study demonstrates that GM soybean intake can influence some liver features during ageing and, although the mechanisms remain unknown, underlines the importance to investigate the long-term consequences of GM-diets and the potential synergistic effects with ageing, xenobiotics and/or stress conditions.
Keywords:Genetically modified soybean, liver, mitochondria
Year of publishing:2008
Number of pages:967-977
Numbering:130
PID:20.500.12556/RUNG-4691-b65690e8-864f-ca8e-ecd4-60d24eb15f64 New window
COBISS.SI-ID:5438971 New window
DOI:10.1007/s00418-008-0476-x New window
NUK URN:URN:SI:UNG:REP:CGFYYCW4
Publication date in RUNG:23.08.2019
Views:3445
Downloads:0
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Record is a part of a journal

Title:Histochemical cellular biology
Shortened title:Histochem Cell Biol
Year of publishing:2008

Licences

License:CC BY-NC-ND 4.0, Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International
Link:http://creativecommons.org/licenses/by-nc-nd/4.0/
Description:The most restrictive Creative Commons license. This only allows people to download and share the work for no commercial gain and for no other purposes.
Licensing start date:22.08.2019

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