| Title: | Connective tissue and diseases: from morphology to proteomics towards the development of new therapeutic appproach |
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| Authors: | ID Quaglino, Daniela, Università di Modena e Reggio Emilia (Author)
ID Boraldi, Federica, Università di Modena e Reggio Emilia (Author)
ID Annovi, Giulia, Università di Modena e Reggio Emilia (Author)
ID Guerra, Deanna, Università di Modena e Reggio Emilia (Author)
ID Pasquali Ronchetti, Ivonne, Università di Modena e Reggio Emilia (Author) |
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| Files: |
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| Language: | English |
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| Work type: | Not categorized |
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| Typology: | 1.02 - Review Article |
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| Organization: | UNG - University of Nova Gorica
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| Abstract: | Connective tissue consists of cells separated by the extracellular matrix, whose composition and amount vary according
to age, to functional requirements, and to the presence of pathologic conditions. Within this non-random
macromolecular assembly, collagens, elastin, proteoglycans and structural glycoproteins are mutually interdependent
and modifications of one component, by extrinsic (environmental) and/or intrinsic (systemic, genetic, age-related)
factors, may have consequences on the tissue as a whole. Since decades, different microscopical techniques have been
applied mainly for diagnostic purposes and for detailed descriptions of changes occurring in cells and in matrix
components. More recently, in order to dissect the molecular complexity of the matrix network, to analyse the
interactions between cells and matrix and to look for modulators of cell phenotype, histomorphologic investigations
have been implemented with proteomic studies that allow to identify possible diagnostic markers, and to better
understand patho-mechanisms enabling the design of novel therapeutic strategies. Therefore, the progressively
expanding, although incomplete, knowledge on connective tissue biology, sheds new light on the pathogenesis of
diseases affecting single molecules (i.e. collagenopathies, mucopolysaccharidoses, elastinopathies) and discloses the
importance of matrix components as fundamental regulators of cell phenotype, in relation, for instance, to the aging
process and/or to cancer development and progression. Few examples will be presented demonstrating the promises of
proteomics as a technique leading to the discovery of new therapies and possibly to the development of individualized
treatments for a better patient care. |
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| Keywords: | pathology, proteomics, fibrosis, rheumatology, cancer |
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| Year of publishing: | 2009 |
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| Number of pages: | 556-565 |
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| Numbering: | 2 |
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| PID: | 20.500.12556/RUNG-4693-5b4924ae-5d81-61d0-c319-23ba8e964fff |
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| COBISS.SI-ID: | 5439995 |
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| NUK URN: | URN:SI:UNG:REP:39TGDV0M |
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| Publication date in RUNG: | 23.08.2019 |
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| Views: | 2905 |
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| Downloads: | 0 |
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