Repository of University of Nova Gorica

Show document
A+ | A- | Help | SLO | ENG

Title:Fibroblast involvement in soft connective tissue calcification
Authors:ID Pasquali Ronchetti, Ivonne, Università di Modena e Reggio Emilia (Author)
ID Boraldi, Federica, Università di Modena e Reggio Emilia (Author)
ID Annovi, Giulia, Università di Modena e Reggio Emilia (Author)
ID Cianciulli, Paolo, S Eugenio Hospital, Rome (Author)
ID Quaglino, Daniela, Università di Modena e Reggio Emilia (Author)
Files: This document has no files that are freely available to the public. This document may have a physical copy in the library of the organization, check the status via COBISS. Link is opened in a new window
Language:English
Work type:Not categorized
Typology:1.02 - Review Article
Organization:UNG - University of Nova Gorica
Abstract:Soft connective tissue calcification is not a passive process, but the consequence of metabolic changes of local mesenchymal cells that, depending on both genetic and environmental factors, alter the balance between pro- and anti-calcifying pathways. While the role of smooth muscle cells and pericytes in ectopic calcifications has been widely investigated, the involvement of fibroblasts is still elusive. Fibroblasts isolated from the dermis of pseudoxanthoma elasticum (PXE) patients and of patients exhibiting PXE-like clinical and histopathological findings offer an attractive model to investigate the mechanisms leading to the precipitation of mineral deposits within elastic fibers and to explore the influence of the genetic background and of the extracellular environment on fibroblast-associated calcifications, thus improving the knowledge on the role of mesenchymal cells on pathologic mineralization.
Keywords:fibroblasts, PXE, PXE-likedisorders, elastin, extracellularmatrix, ectopiccalcification, mesenchymal stromalcells
Year of publishing:2013
Number of pages:1-16
Numbering:4
PID:20.500.12556/RUNG-4699-a015d0fb-c66f-874e-40c0-aa8b4ad3fbe8 New window
COBISS.SI-ID:5442043 New window
NUK URN:URN:SI:UNG:REP:NR53OB9M
Publication date in RUNG:23.08.2019
Views:3405
Downloads:0
Metadata:XML RDF-CHPDL DC-XML DC-RDF
:
Copy citation
  
Average score:(0 votes)
Your score:Voting is allowed only for logged in users.
Share:Bookmark and Share


Hover the mouse pointer over a document title to show the abstract or click on the title to get all document metadata.

Record is a part of a journal

Title:Frontiers in genetics
Year of publishing:2013

Licences

License:CC BY-NC-ND 4.0, Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International
Link:http://creativecommons.org/licenses/by-nc-nd/4.0/
Description:The most restrictive Creative Commons license. This only allows people to download and share the work for no commercial gain and for no other purposes.
Licensing start date:22.08.2019

Back