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Title:Effects of alfaxalone or propofol on giant-breed dog neonates viability during elective caesarean sections
Authors:ID Melandri, Monica, Società Veterinaria “Il Melograno” Srl, 21018 Sesto Calende, Varese, Italy (Author)
ID Peric, Tanja, Department of Agricultural, Food, Environmental and Animal Sciences, University of Udine, Udine, 33100, Italy (Author), et al.
Files:.pdf animals-09-00962.pdf (234,45 KB)
MD5: CDE4CC4085E9A5836E79A375AD9FF3DE
 
Language:English
Work type:Not categorized
Typology:1.01 - Original Scientific Article
Organization:UNG - University of Nova Gorica
Abstract:Attention must be paid to C-section anesthesia effects on mother and offspring. Alfaxalone induction results in improved puppy viability when compared to propofol. The present study aims to evaluate effects of alfaxalone or propofol induction for elective C-section on newborns, expressed as Apgar score and fetal fluids cortisol concentration. Anesthesia was induced with alfaxalone 3 mg/kg iv in 5 bitches (group A), and propofol 4 mg/kg iv in another 5 (group P), maintained with isoflurane. Amniotic and allantoic fluids were collected to determine cortisol concentration. Apgar score, litter size, newborn gender, birth-weight, maternal age, and parity were recorded. ANOVA, U Mann-Whitney test and ANCOVA assessed the effects of drugs on the Apgar score and fetal fluids cortisol. Thirty-six puppies were randomly selected for the study: 16 from group A and 20 from group P. Only the Apgar score significantly differed between groups. ANCOVA confirmed a significantly higher Apgar score in group A underlining the influence of fetal fluids cortisol concentrations, both resulting in covariates. Present results confirm the effect of anesthesia on the Apgar score of newborns, which is significantly higher for alfaxalone than propofol, suggesting the use of fetal fluids cortisol as a covariate. These findings could be a starting point for further investigations when less viable puppies are detected or expected, such as during an emergency C-section. © 2019 by the authors. Licensee MDPI, Basel, Switzerland.
Keywords:Alfaxalone, Apgar score, C-section, Canine neonates, Cortisol, Fetal fluids
Publication status:Published
Publication version:Author Accepted Manuscript
Year of publishing:2019
Number of pages:11
Numbering:2019, 9
PID:20.500.12556/RUNG-4880-73a7c638-1534-6200-19ca-7d5637e30274 New window
COBISS.SI-ID:5485563 New window
DOI:10.3390/ani9110962 New window
NUK URN:URN:SI:UNG:REP:AIYHD2IL
Publication date in RUNG:26.11.2019
Views:3107
Downloads:96
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Record is a part of a journal

Title:Animals
Year of publishing:2019
ISSN:20762615

Licences

License:CC BY-NC-ND 4.0, Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International
Link:http://creativecommons.org/licenses/by-nc-nd/4.0/
Description:The most restrictive Creative Commons license. This only allows people to download and share the work for no commercial gain and for no other purposes.
Licensing start date:26.11.2019

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