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Title:Diversity of bacteria and bacterial products as antibiofilm and antiquorum sensing drugs against pathogenic bacteria
Authors:Khan, Fazlurrahman (Author)
Oloketuyi, Sandra (Author)
Kim, Young-Mog (Author)
Files:This document has no files. This document may have a phisical copy in the library of the organization, check the status via COBISS. Link is opened in a new window
Language:English
Work type:Not categorized (r6)
Tipology:1.02 - Review Article
Organization:UNG - University of Nova Gorica
Abstract:The increase in antibiotic resistance of pathogenic bacteria has led to the development of new therapeutic approaches to inhibit biofilm formation as well as interfere quorum sensing (QS) signaling systems. The QS system is a phenomenon in which pathogenic bacteria produce signaling molecules that are involved in cell to cell communication, production of virulence factors, biofilm maturation, and several other functions. In the natural environment, several non-pathogenic bacteria are present as mixed population along with pathogenic bacteria and they control the behavior of microbial community by producing secondary metabolites. Similarly, non-pathogenic bacteria also take advantages of the QS signaling molecule as a sole carbon source for their growth through catabolism with enzymes. Several enzymes are produced by bacteria which disrupt the biofilm architecture by degrading the composition of extracellular polymeric substances (EPS) such as exopolysaccharide, extracellular- DNA and protein. Thus, the interference of QS system by bacterial metabolic products and enzymatic catalysis, modification of the QS signaling molecules as well as enzymatic disruption of biofilm architecture have been considered as the alternative therapeutic approaches. This review article elaborates on the diversity of different bacterial species with respect to their metabolic products as well as enzymes and their molecular modes of action. The bacterial enzymes and metabolic products will open new and promising perspectives for the development of strategies against the pathogenic bacterial infections.
Keywords:Bacteria, biofilm, quorum sensing, inhibition, metabolites, pathogen, virulence.
Year of publishing:2019
Number of pages:1156-1179
Numbering:20, 11
COBISS_ID:47521283 Link is opened in a new window
URN:URN:SI:UNG:REP:TYJAD5KU
DOI:10.2174/1389450120666190423161249 Link is opened in a new window
License:CC BY-ND 4.0
This work is available under this license: Creative Commons Attribution No Derivatives 4.0 International
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Record is a part of a journal

Title:Current Drug Targets
Shortened title:Curr. Drug Targets
Year of publishing:2019

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