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Title:Diversity of bacteria and bacterial products as antibiofilm and antiquorum sensing drugs against pathogenic bacteria
Authors:ID Khan, Fazlurrahman, Marine-Integrated Bionics Research Center, Pukyong National University, Busan 48513, South Korea (Author)
ID Oloketuyi, Sandra, Laboratory for Environmental and Life Sciences, University of Nova Gorica, 5000, Slovenia (Author)
ID Kim, Young-Mog, Marine-Integrated Bionics Research Center, Pukyong National University, Busan 48513, South Korea (Author)
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Language:English
Work type:Not categorized
Typology:1.02 - Review Article
Organization:UNG - University of Nova Gorica
Abstract:The increase in antibiotic resistance of pathogenic bacteria has led to the development of new therapeutic approaches to inhibit biofilm formation as well as interfere quorum sensing (QS) signaling systems. The QS system is a phenomenon in which pathogenic bacteria produce signaling molecules that are involved in cell to cell communication, production of virulence factors, biofilm maturation, and several other functions. In the natural environment, several non-pathogenic bacteria are present as mixed population along with pathogenic bacteria and they control the behavior of microbial community by producing secondary metabolites. Similarly, non-pathogenic bacteria also take advantages of the QS signaling molecule as a sole carbon source for their growth through catabolism with enzymes. Several enzymes are produced by bacteria which disrupt the biofilm architecture by degrading the composition of extracellular polymeric substances (EPS) such as exopolysaccharide, extracellular- DNA and protein. Thus, the interference of QS system by bacterial metabolic products and enzymatic catalysis, modification of the QS signaling molecules as well as enzymatic disruption of biofilm architecture have been considered as the alternative therapeutic approaches. This review article elaborates on the diversity of different bacterial species with respect to their metabolic products as well as enzymes and their molecular modes of action. The bacterial enzymes and metabolic products will open new and promising perspectives for the development of strategies against the pathogenic bacterial infections.
Keywords:Bacteria, biofilm, quorum sensing, inhibition, metabolites, pathogen, virulence.
Year of publishing:2019
Number of pages:1156-1179
Numbering:11, 20
PID:20.500.12556/RUNG-6194 New window
COBISS.SI-ID:47521283 New window
DOI:10.2174/1389450120666190423161249 New window
NUK URN:URN:SI:UNG:REP:TYJAD5KU
Publication date in RUNG:18.01.2021
Views:4286
Downloads:0
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KHAN, Fazlurrahman, OLOKETUYI, Sandra and KIM, Young-Mog, 2019, Diversity of bacteria and bacterial products as antibiofilm and antiquorum sensing drugs against pathogenic bacteria. Current Drug Targets [online]. 2019. Vol. 11, no. 20, p. 1156–1179. [Accessed 11 April 2025]. DOI 10.2174/1389450120666190423161249. Retrieved from: https://repozitorij.ung.si/IzpisGradiva.php?lang=eng&id=6194
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Record is a part of a journal

Title:Current Drug Targets
Shortened title:Curr. Drug Targets
Year of publishing:2019

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License:CC BY-ND 4.0, Creative Commons Attribution-NoDerivatives 4.0 International
Link:http://creativecommons.org/licenses/by-nd/4.0/
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Licensing start date:14.01.2021

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