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Title:Chitosan and their derivatives: Antibiofilm drugs against pathogenic bacteria
Authors:ID Khan, Fazlurrahman (Author)
ID Pham, Dong (Author)
ID Oloketuyi, Sandra (Author)
ID Manivasagan, Panchanathan (Author)
ID Oh, Junghwan (Author)
ID Kim, Young-Mog (Author)
Files: This document has no files that are freely available to the public. This document may have a physical copy in the library of the organization, check the status via COBISS. Link is opened in a new window
Work type:Not categorized
Typology:1.02 - Review Article
Organization:UNG - University of Nova Gorica
Abstract:Biofilm formed by several pathogenic bacteria results in the development of resistance against antimicrobial compounds. The polymeric materials present in the biofilm architecture hinder the entry of antimicrobial compounds through the surface of bacterial cells which are embedded as well as enclosed beneath the biofilm matrix. Recent and past studies explored the alternative approaches to inhibit the formation of biofilm by different agents isolated from plants, animals, and microbes. Among these agents, chitosan and its derivatives have got more attention due to their properties such as biodegradability, biocompatibility, non-allergenic and non-toxicity. Recent researches have focused on employing chitosan and its derivatives as effective agents to inhibit biofilm formation and attenuate virulence properties by various pathogenic bacteria. Such antibiofilm activity of chitosan and its derivatives can be further enhanced by conjugation with a wide range of bioactive compounds. The present review describes the antibiofilm properties of chitosan and its derivatives against the pathogenic bacteria. This review also summarizes the mechanisms of biofilm inhibition exhibited by these molecules. The knowledge of the antibiofilm activities of chitosan and its derivatives as well as their underlying mechanisms provides essential insights for widening their applications in the future.
Keywords:Antibiofilm, Biofilm inhibition, Chitosan, Chitosan derivatives, Pathogenic bacteria
Year of publishing:2020
Number of pages:53
Numbering:2020, 185
PID:20.500.12556/RUNG-6204 New window
COBISS.SI-ID:47102979 New window
DOI:10.1016/j.colsurfb.2019.110627 New window
Publication date in RUNG:14.01.2021
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Title:Colloids and Surfaces B: Biointerfaces
Year of publishing:2020