| Title: | Untargeted molecular analysis of exhaled breath as a diagnostic test for ventilator-associated lower respiratory tract infections (BreathDx) |
|---|
| Authors: | Oort, Pouline M. van (Author)
Nijsen, Tamara M. E. (Author)
White, Iain R. (Author)
Knobel, Hugo (Author)
Felton, Timothy (Author)
Rattray, Nicholas J. W. (Author)
Lawal, Oluwasola (Author)
Bulut, Murtaza (Author)
Ahmed, Waqar (Author)
Artigas, Antonio (Author) |
|---|
| Files: | This document has no files. This document may have a phisical copy in the library of the organization, check the status via COBISS.  |
|---|
| Language: | English |
|---|
| Work type: | Unknown () |
|---|
| Tipology: | 1.03 - Short Scientific Article |
|---|
| Organization: | UNG - University of Nova Gorica |
|---|
| Abstract: | Patients suspected of ventilator-associated lower respiratory tract infections (VA-LRTIs) commonly receive broad-spectrum antimicrobial therapy unnecessarily. We tested whether exhaled breath analysis can discriminate between patients suspected of VA-LRTI with confirmed infection, from patients with negative cultures. Breath from 108 patients suspected of VA-LRTI was analysed by gas chromatography-mass spectrometry. The breath test had a sensitivity of 98% at a specificity of 49%, confirmed with a second analytical method. The breath test had a negative predictive value of 96% and excluded pneumonia in half of the patients with negative cultures. Trial registration number: UKCRN ID number 19086, registered May 2015. |
|---|
| Keywords: | ventilator-associated pneumonia, breath analysis, volatile organic compounds, metabolomics, intensive care, hospital acquired infections |
|---|
| Year of publishing: | 2021 |
|---|
| Number of pages: | str. 1-3 |
|---|
| Numbering: | iss. , Vol. |
|---|
| COBISS_ID: | 75487235 |
|---|
| UDC: | 616.2 |
|---|
| ISSN on article: | 0040-6376 |
|---|
| URN: | URN:SI:UNG:REP:PVOIQNHM |
|---|
| DOI: | 10.1136/thoraxjnl-2021-217362 |
|---|
| Views: | 1232 |
|---|
| Downloads: | 0 |
|---|
| Metadata: |     |
|---|
| Categories: | Document is not linked to any category. |
|---|
|
:
|
|
|---|
| | | | Average score: | (0 votes) |
|---|
| Your score: | Voting is allowed only for logged in users. |
|---|
Hover the mouse pointer over a document title to show the abstract or click
on the title to get all document metadata. |