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Title:Breath and plasma metabolomics to assess inflammation in acute stroke
Authors:ID Ahmed, Waqar (Author)
ID White, Iain R. (Author)
ID Wilkinson, Maxim (Author)
ID Johnson, Craig (Author)
ID Rattray, Nicholas J. W. (Author)
ID Kishore, Amit K. (Author)
ID Goodacre, Royston (Author)
ID Smith, Craig J. (Author)
ID Fowler, Stephen J. (Author)
Work type:Unknown
Typology:1.01 - Original Scientific Article
Organization:UNG - University of Nova Gorica
Abstract:Inflammation is strongly implicated in both injury and repair processes occurring after stroke. In this exploratory study we assessed the feasibility of repeated sampling of exhaled volatile organic compounds and performed an untargeted metabolomic analysis of plasma collected at multiple time periods after stroke. Metabolic profiles were compared with the time course of the inflammatory markers C-reactive protein (CRP) and interleukin-6 (IL-6). Serial breath sampling was well-tolerated by all patients and the measurement appears feasible in this group. We found that exhaled decanal tracks CRP and IL-6 levels post-stroke and correlates with several metabolic pathways associated with a post-stroke inflammatory response. This suggests that measurement of breath and blood metabolites could facilitate development of novel therapeutic and diagnostic strategies. Results are discussed in relation to the utility of breath analysis in stroke care, such as in monitoring recovery and complications including stroke associated infection.
Keywords:stroke, metabolomics, breath, VOCs, inflammation
Year of publishing:2021
Number of pages:str. 1-14
Numbering:Vol. 11, 11
PID:20.500.12556/RUNG-6989 New window
COBISS.SI-ID:85403907 New window
ISSN on article:2045-2322
DOI:10.1038/s41598-021-01268-5 New window
Publication date in RUNG:18.11.2021
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Record is a part of a journal

Title:Scientific reports
Shortened title:Sci. rep.
Publisher:Nature Publishing Group
COBISS.SI-ID:18727432 New window