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Title:Pharmacological application of thermal Lens technique - A thermal diffusivity study
Authors:ID Swapna, Mohanachandran Nair Sindhu, UNIVERSITY OF KERALA (Author), et al.
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Language:English
Work type:Not categorized
Typology:1.01 - Original Scientific Article
Organization:UNG - University of Nova Gorica
Abstract:The photothermal phenomenon has emerged as a potential tool for the nondestructive evaluation of thermal and optical properties of materials. Thermal analysis of drugs is an unavoidable part of preformulation study, as temperature variations can induce structural changes of the constituents of drugs. Techniques based on photothermal phenomena are highly sensitive, as only the absorbed radiation contributes to the signal. Periodic illumination and subsequent nonradiative de-excitation generate thermal lens signals of various types within and around the sample. Variation of thermal diffusivity with a concentration of the commonly used drug terbutaline is studied through the single-beam thermal lens technique. The ultraviolet–visible spectrum of the drug shows strong absorption around 500 nm, which suggests the possible wavelengths that can be used for the study. It is found that concentration of the drug in liquid form decides its thermal stability, as its thermal diffusivity varies with concentration. The study gives information about the optimum value for the concentration of the drug noted above for which the chance of thermal stability is high.
Keywords:thermal lens, thermal diffusivity, pharmacology, drug
Publication version:Version of Record
Year of publishing:2018
Number of pages:4
Numbering:7, 35
PID:20.500.12556/RUNG-7423 New window
COBISS.SI-ID:113430275 New window
DOI:https://doi.org/10.1364/JOSAB.35.001662 New window
NUK URN:URN:SI:UNG:REP:K00FLWLT
Publication date in RUNG:30.06.2022
Views:2079
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SWAPNA, Mohanachandran Nair Sindhu, 2018, Pharmacological application of thermal Lens technique - A thermal diffusivity study. Journal of the Optical Society of America B [online]. 2018. Vol. 7, no. 35. [Accessed 26 March 2025]. DOI https://doi.org/10.1364/JOSAB.35.001662. Retrieved from: https://repozitorij.ung.si/IzpisGradiva.php?lang=eng&id=7423
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Record is a part of a journal

Title:Journal of the Optical Society of America B
Publisher:OPTICAL SOCIETY OF AMERICA
Year of publishing:2018
ISSN:1520-8540

Licences

License:CC BY-NC-ND 4.0, Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International
Link:http://creativecommons.org/licenses/by-nc-nd/4.0/
Description:The most restrictive Creative Commons license. This only allows people to download and share the work for no commercial gain and for no other purposes.
Licensing start date:29.06.2022

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