| Title: | Engineering of functional nanosnowflakes from gold nanocarriers capped with amino-modified DNA oligonucleotides |
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| Authors: | ID Loukanov, Alexandre (Author)
ID Arahangelova, Velichka (Author)
ID Emin, Saim (Author)
ID Filipov, Chavdar (Author) |
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| Files: |
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| Language: | English |
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| Work type: | Unknown |
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| Typology: | 1.01 - Original Scientific Article |
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| Organization: | UNG - University of Nova Gorica
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| Abstract: | Abstract
The design, engineering and electron microscopic characterization of anisotropic nanosized snowflake‐like structural assemblies (nanosnowflakes) is reported. They were fabricated through immobilization of double stranded amine‐modified and thiol‐terminated DNA oligonucleotides on the surface of ultra‐small isotropic gold nanoparticles used as nanocarriers. The transmission electron microscopy images combined with spectrophotometric data revealed the formation of self‐assembled structural aggregation between individual ligands‐coated nanoparticles. They act as seeds for the further spontaneous dendritic growth in different directions. Their anisotropic morphology is formed due to the occurrence of facilitated electrostatic interactions between positive charged amino‐groups and the negative sugar‐phosphate backbone of oligonucleotides. Thus, nanosnowflakes with size distribution between 40 and 80 nm were obtained. The microscopic analysis demonstrated also that the stable nanosnowflakes structure was highly dependent on the solution ionic strength, which effect the charge fluctuation within the assembly. The reported DNA functionalized nanostructures have potential to be applied as a platform for development of therapeutic materials, as well as drug delivery nanosystems.
Research Highlights
The engineering, fabrication, and microscopic characterization of DNA nanosnowflakes is reported.
The electron microscopy analysis revealed formation of self‐assemblies with anisotropic morphology.
The nanosnowflakes size distribution was between 40 and 80 nm. |
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| Keywords: | DNA, nanocarrier, functionalization, drug delivery |
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| Publication status: | Published |
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| Publication version: | Version of Record |
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| Publication date: | 01.01.2023 |
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| Year of publishing: | 2023 |
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| Number of pages: | str. 1169-1176 |
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| Numbering: | Vol. 86, issue 9 |
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| PID: | 20.500.12556/RUNG-8944 |
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| COBISS.SI-ID: | 189340419 |
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| ISSN: | 1059-910X |
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| UDC: | 54 |
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| ISSN on article: | 1059-910X |
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| eISSN: | 1097-0029 |
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| DOI: | 10.1002/jemt.24390 |
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| NUK URN: | URN:SI:UNG:REP:XBDFAGUO |
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| Publication date in RUNG: | 18.03.2024 |
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| Views: | 1379 |
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| Downloads: | 0 |
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