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Title:Engineering of functional nanosnowflakes from gold nanocarriers capped with amino-modified DNA oligonucleotides
Authors:ID Loukanov, Alexandre (Author)
ID Arahangelova, Velichka (Author)
ID Emin, Saim (Author)
ID Filipov, Chavdar (Author)
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Language:English
Work type:Unknown
Typology:1.01 - Original Scientific Article
Organization:UNG - University of Nova Gorica
Abstract:Abstract The design, engineering and electron microscopic characterization of anisotropic nanosized snowflake‐like structural assemblies (nanosnowflakes) is reported. They were fabricated through immobilization of double stranded amine‐modified and thiol‐terminated DNA oligonucleotides on the surface of ultra‐small isotropic gold nanoparticles used as nanocarriers. The transmission electron microscopy images combined with spectrophotometric data revealed the formation of self‐assembled structural aggregation between individual ligands‐coated nanoparticles. They act as seeds for the further spontaneous dendritic growth in different directions. Their anisotropic morphology is formed due to the occurrence of facilitated electrostatic interactions between positive charged amino‐groups and the negative sugar‐phosphate backbone of oligonucleotides. Thus, nanosnowflakes with size distribution between 40 and 80 nm were obtained. The microscopic analysis demonstrated also that the stable nanosnowflakes structure was highly dependent on the solution ionic strength, which effect the charge fluctuation within the assembly. The reported DNA functionalized nanostructures have potential to be applied as a platform for development of therapeutic materials, as well as drug delivery nanosystems. Research Highlights The engineering, fabrication, and microscopic characterization of DNA nanosnowflakes is reported. The electron microscopy analysis revealed formation of self‐assemblies with anisotropic morphology. The nanosnowflakes size distribution was between 40 and 80 nm.
Keywords:DNA, nanocarrier, functionalization, drug delivery
Publication status:Published
Publication version:Version of Record
Publication date:01.01.2023
Year of publishing:2023
Number of pages:str. 1169-1176
Numbering:Vol. 86, issue 9
PID:20.500.12556/RUNG-8944 New window
COBISS.SI-ID:189340419 New window
ISSN:1059-910X
UDC:54
ISSN on article:1059-910X
eISSN:1097-0029
DOI:10.1002/jemt.24390 New window
NUK URN:URN:SI:UNG:REP:XBDFAGUO
Publication date in RUNG:18.03.2024
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Record is a part of a journal

Title:Microscopy research and technique
Shortened title:Microsc. res. tech.
Publisher:Wiley-Liss
ISSN:1059-910X
COBISS.SI-ID:1730383 New window

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License:Other
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Licensing start date:21.07.2023

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