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Title:Metabolic dysregulation in vitamin E and carnitine shuttle energy mechanisms associate with human frailty
Authors:Rattray, Nicholas (Author)
Trivedi, Drupad (Author)
Xu, Yun (Author)
Chandola, Tarani (Author)
Johnson, Caroline (Author)
Marshall, Alan (Author)
Mekli, Krisztina (Author)
Rattray, Zahra (Author)
Tampubolon, Gindo (Author)
Vanhoutte, Bram (Author)
White, Iain (Author)
Wu, Frederick (Author)
Pendleton, Neil (Author)
Nazroo, James (Author)
Goodacre, Royston (Author)
Files:.pdf s41467-019-12716-2.pdf (2,35 MB)
Work type:Not categorized (r6)
Tipology:1.01 - Original Scientific Article
Organization:UNG - University of Nova Gorica
Abstract:Global ageing poses a substantial economic burden on health and social care costs. Enabling a greater proportion of older people to stay healthy for longer is key to the future sustainability of health, social and economic policy. Frailty and associated decrease in resilience plays a central role in poor health in later life. In this study, we present a population level assessment of the metabolic phenotype associated with frailty. Analysis of serum from 1191 older individuals (aged between 56 and 84 years old) and subsequent longitudinal validation (on 786 subjects) was carried out using liquid and gas chromatography-mass spectrometry metabolomics and stratified across a frailty index designed to quantitatively summarize vulnerability. Through multivariate regression and network modelling and mROC modeling we identified 12 significant metabolites (including three tocotrienols and six carnitines) that differentiate frail and non-frail phenotypes. Our study provides evidence that the dysregulation of carnitine shuttle and vitamin E pathways play a role in the risk of frailty.
Keywords:metabolomics, frailty, ageing, LC-MS, serum
Year of publishing:2019
Number of pages:12
COBISS_ID:5478907 Link is opened in a new window
DOI:doi:10.1038/s41467-019-12716-2 Link is opened in a new window
License:CC BY-NC-SA 4.0
This work is available under this license: Creative Commons Attribution Non-Commercial Share Alike 4.0 International
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Record is a part of a journal

Title:Nature Communications
Publisher:Nature Publishing Group
Year of publishing:2019